Bao-Jing Zhang

Bio: Bao-Jing Zhang is an academic researcher from Dalian Medical University. The author has contributed to research in topics: Schiff base & Imine. The author has an hindex of 3, co-authored 5 publications receiving 35 citations.

catena-Poly[[{2,4-dichloro-6-[2-(ethylamino)ethyliminomethyl]phenolato}copper(II)]-μ-azido]

Abstract: The title compound, [Cu(C11H13Cl2N2O)(N3)]n, is an azide-bridged polymeric copper(II) complex. The Cu atom is penta­coordinated by one O and two N atoms of the Schiff base ligand and two bridging N atoms from two azide groups, forming a trigonal–bipyramidal geometry. The structure is further stabilized by an N—H⋯O hydrogen bond.

PP2A as the Main Node of Therapeutic Strategies and Resistance Reversal in Triple-Negative Breast Cancer.

Abstract: Triple negative breast cancer (TNBC), is defined as a type of tumor lacking the expression of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). The ER, PR and HER2 are usually the molecular therapeutic targets for breast cancers, but they are ineffective for TNBC because of their negative expressions, so chemotherapy is currently the main treatment strategy in TNBC. However, drug resistance remains a major impediment to TNBC chemotherapeutic treatment. Recently, the protein phosphatase 2A (PP2A) has been found to regulate the phosphorylation of some substrates involved in the relevant target of TNBC, such as cell cycle control, DNA damage responses, epidermal growth factor receptor, immune modulation and cell death resistance, which may be the effective therapeutic strategies or influence drug sensitivity to TNBCs. Furthermore, PP2A has also been found that could induce ER re-expression in ER-negative breast cancer cells, and which suggests PP2A could promote the sensitivity of tamoxifen to TNBCs as a resistance reversal agent. In this review, we will summarize the potential therapeutic value of PP2A as the main node in developing targeting agents, disrupting resistance or restoring drug sensitivity in TNBC.

Azido{1‐[(2‐diethylaminoethylimino‐κ2N,N′)methyl]naphthalen‐2‐olato‐κO}nickel(II)

Abstract: In the title mononuclear nickel(II) complex, [Ni(C17H21N2O)(N3)], the NiII atom is four-coordinated by the phenolate O, imine N and amine N atoms of one Schiff base ligand, and by the terminal N atom of an azido ligand, forming a square-planar geometry

Diphenyl vinyl pyridine compound, composition and application thereof

Abstract: The invention relates to a diphenyl vinyl pyridine compound, a composition and application thereof. The diphenyl vinyl pyridine compound is specifically a compound shown by a general formula (I); and each substituent group of the general formula (I) is as shown by the definition in the specification. The invention also relates to application of the compound as shown in the general formula (I), pharmaceutically acceptable salts thereof or the pharmaceutical composition containing the same. The compound, the pharmaceutically acceptable salts thereof or the pharmaceutical composition containing the same is used for suppressing epidermal growth factor receptor (EGFR) protein tyrosine kinase to further treat tumor diseases, in particular, to treat non-small cell lung cancers, small cell lung cancers, squamous-cell carcinoma or pancreatic cancers.

Prognostic Value of Tumor-Infiltrating Lymphocytes in Triple-Negative Breast Cancers From Two Phase III Randomized Adjuvant Breast Cancer Trials: ECOG 2197 and ECOG 1199

Abstract: Purpose Recent studies suggest that tumor-infiltrating lymphocytes (TILs) are associated with disease-free (DFS) and overall survival (OS) in operable triple-negative breast cancer (TNBC). We seek to validate the prognostic impact of TILs in primary TNBCs in two adjuvant phase III trials conducted by the Eastern Cooperative Oncology Group (ECOG). Patients and methods Full-face hematoxylin and eosin–stained sections of 506 tumors from ECOG trials E2197 and E1199 were evaluated for density of TILs in intraepithelial (iTILs) and stromal compartments (sTILs). Patient cases of TNBC from E2197 and E1199 were randomly selected based on availability of sections. For the primary end point of DFS, association with TIL scores was determined by fitting proportional hazards models stratified on study. Secondary end points were OS and distant recurrence–free interval (DRFI). Reporting recommendations for tumor marker prognostic studies criteria were followed, and all analyses were prespecified. Results The majority of 481 evaluable cancers had TILs (sTILs, 80%; iTILs, 15%). With a median follow-up of 10.6 years, higher sTIL scores were associated with better prognosis; for every 10% increase in sTILs, a 14% reduction of risk of recurrence or death (P = .02), 18% reduction of risk of distant recurrence (P = .04), and 19% reduction of risk of death (P = .01) were observed. Multivariable analysis confirmed sTILs to be an independent prognostic marker of DFS, DRFI, and OS. Conclusion In two national randomized clinical trials using contemporary adjuvant chemotherapy, we confirm that stromal lymphocytic infiltration constitutes a robust prognostic factor in TNBCs. Studies assessing outcomes and therapeutic efficacies should consider stratification for this parameter.

Magneto-Structural Correlation Studies and Theoretical Calculations of a Unique Family of Single End-to-End Azide-Bridged NiII4 Cyclic Clusters

Abstract: The work in this paper aims to portray a complete structural, magnetic, and theoretical description of two original end-to-end (EE) μ1,3-azide-bridged, cyclic tetranuclear NiII clusters, [{NiII(L1)(μ1,3-N3)(H2O)}4] (1) and [{NiII(L2)(μ1,3-N3)(H2O)}4] (2), where the ligands used to achieve these species, HL1 and HL2, are the tridentate Schiff base ligands obtained from [1 + 1] condensations of salicylaldehyde with 1-(2-aminoethyl)-piperidine and 4-(2-aminoethyl)-morpholine, respectively. The title compounds, 1 and 2, crystallize in a monoclinic P21 space group. Overall, both species can be described in a similar way; where all NiII centers within each molecule are hexacoordinated and bound to [L1]− or [L2]− through the phenoxo oxygen, imine nitrogen, and piperidine/morpholine nitrogen atoms of the corresponding ligand. The remaining coordination sites are satisfied by one molecule of H2O and two nitrogen atoms from N3− anions. The latest act as bridges between NiII ions, and eventually, only four azido gro...

(E)-N'-(2-Hy-droxy-benzyl-idene)furan-2-carbohydrazide.

Abstract: In the title compound, C12H10N2O3, the dihedral angle between the benzene ring and the furan ring is 16.12 (13)°. The conformation is stabilized by an intra­molecular O—H⋯N hydrogen bond. Inter­molecular N—H⋯O hydrogen bonds with the keto group as acceptor lead to strands along [001]. The mol­ecule displays a trans configuration with respect to the C=N and N—N bonds.