Author
Bao-Xiang Zhao
Other affiliations: Changwon National University
Bio: Bao-Xiang Zhao is an academic researcher from Shandong University. The author has contributed to research in topics: Fluorescence & Pyrazole. The author has an hindex of 48, co-authored 258 publications receiving 7136 citations. Previous affiliations of Bao-Xiang Zhao include Changwon National University.
Topics: Fluorescence, Pyrazole, Apoptosis, Autophagy, Endothelial stem cell
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors summarized and highlighted the recent advances in the development and application of HOCl fluorescent probes, and divided the HOCl fluorescence probes into five parts and discussed detection mechanisms, respectively.
Abstract: As one of the reactive oxygen species, hypochlorous acid (HOCl) may be associated with various diseases. To understand the roles of HOCl in living organism, fluorescent probes for imaging HOCl in living systems have been developed fast in recent years owing to their high selectivity, excellent sensitivity and spectral resolution. In this review, we summarized and highlighted the recent advances in the development and application of HOCl fluorescent probes. This review is focused on the detection mechanisms of probes for HOCl. According to the various recognition groups, we divided the HOCl fluorescence probes into five parts and discussed detection mechanisms, respectively.
197 citations
TL;DR: A series of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives were synthesized and the effects of all the compounds on A549 cell growth were investigated, showing that all compounds had almost inhibitory effects on the growth of A549 cells.
191 citations
TL;DR: The data suggested that CQ inhibited A549 lung cancer cell growth at lower concentrations by increasing the volume of lysosomes and that PC-PLC might be involved in this process, but the data also indicated that, at higher concentrations, CQ induced apoptosis and necrosis, but at this time its ability to increase theVolume ofLysosome gradually declined, and PC- PLC might not be implicated in the process.
167 citations
TL;DR: HCy-D showed a ratiometric, sensitive and rapid response to HSO3(-)/SO3(2-) and was successfully used for fluorescence imaging of endogenous bisulfite in HepG2 cells, which may benefit cancer diagnosis by discriminating liver cancer cells from normal liver cells.
161 citations
TL;DR: A new ratiometric fluorescent probe composed of a coumarin-merocyanine dyad based on the FRET mechanism showed clear dual-emission signal changes in blue and red spectral windows upon addition of H2S in a dose dependent manner under a single wavelength excitation.
151 citations
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TL;DR: Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210046, P. R. China.
Abstract: Yuming Yang,†,§ Qiang Zhao,‡,§ Wei Feng,† and Fuyou Li*,† †Department of Chemistry and State Key Laboratory of Molecular Engineering of Polymers and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, P. R. China ‡Key Laboratory for Organic Electronics and Information Displays (KLOEID) and Institute of Advanced Materials (IAM), Nanjing University of Posts and Telecommunications, Nanjing 210046, P. R. China.
1,999 citations
01 Feb 1995
TL;DR: In this paper, the unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio using DFT, MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set.
Abstract: : The unpolarized absorption and circular dichroism spectra of the fundamental vibrational transitions of the chiral molecule, 4-methyl-2-oxetanone, are calculated ab initio. Harmonic force fields are obtained using Density Functional Theory (DFT), MP2, and SCF methodologies and a 5S4P2D/3S2P (TZ2P) basis set. DFT calculations use the Local Spin Density Approximation (LSDA), BLYP, and Becke3LYP (B3LYP) density functionals. Mid-IR spectra predicted using LSDA, BLYP, and B3LYP force fields are of significantly different quality, the B3LYP force field yielding spectra in clearly superior, and overall excellent, agreement with experiment. The MP2 force field yields spectra in slightly worse agreement with experiment than the B3LYP force field. The SCF force field yields spectra in poor agreement with experiment.The basis set dependence of B3LYP force fields is also explored: the 6-31G* and TZ2P basis sets give very similar results while the 3-21G basis set yields spectra in substantially worse agreements with experiment. jg
1,652 citations
01 Aug 2010
TL;DR: In this paper, the identification of lincRNAs (lincRNA-p21) that serve as a repressor in p53-dependent transcriptional responses was reported, and the observed transcriptional repression was mediated through the physical association with hnRNP-K at repressed genes and regulation of p53 mediates apoptosis.
Abstract: Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported. These RNAs are evolutionarily conserved in mammalian genomes and thus presumably function in diverse biological processes. Here, we report the identification of lincRNAs that are regulated by p53. One of these lincRNAs (lincRNA-p21) serves as a repressor in p53-dependent transcriptional responses. Inhibition of lincRNA-p21 affects the expression of hundreds of gene targets enriched for genes normally repressed by p53. The observed transcriptional repression by lincRNA-p21 is mediated through the physical association with hnRNP-K. This interaction is required for proper genomic localization of hnRNP-K at repressed genes and regulation of p53 mediates apoptosis. We propose a model whereby transcription factors activate lincRNAs that serve as key repressors by physically associating with repressive complexes and modulate their localization to sets of previously active genes.
1,593 citations