B
Baogong Zhu
Researcher at Harvard University
Publications - 18
Citations - 9412
Baogong Zhu is an academic researcher from Harvard University. The author has contributed to research in topics: T cell & Cytotoxic T cell. The author has an hindex of 14, co-authored 18 publications receiving 8503 citations. Previous affiliations of Baogong Zhu include Brigham and Women's Hospital.
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Journal ArticleDOI
Restoring function in exhausted CD8 T cells during chronic viral infection.
Daniel L. Barber,E. John Wherry,David Masopust,Baogong Zhu,James P. Allison,Arlene H. Sharpe,Gordon J. Freeman,Rafi Ahmed +7 more
TL;DR: In this article, the authors analyzed genes expressed in functionally impaired virus-specific CD8 T cells present in mice chronically infected with lymphocytic choriomeningitis virus (LCMV), and compared these with the gene profile of functional memory CD8T cells.
Journal ArticleDOI
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
Cheryl L. Day,Daniel Kaufmann,Photini Kiepiela,Julia A. Brown,Eshia Moodley,Sharon Reddy,Elizabeth W Mackey,Joseph D. Miller,Alasdair Leslie,Chantal DePierres,Zenele Mncube,Jaikumar Duraiswamy,Baogong Zhu,Quentin Eichbaum,Marcus Altfeld,E. John Wherry,Hoosen M. Coovadia,Philip J. R. Goulder,Philip J. R. Goulder,Philip J. R. Goulder,Paul Klenerman,Rafi Ahmed,Gordon J. Freeman,Bruce D. Walker,Bruce D. Walker,Bruce D. Walker +25 more
TL;DR: The data indicate that the immunoregulatory PD-1/PD-L1 pathway is operative during a persistent viral infection in humans, and define a reversible defect in HIV-specific T-cell function.
Journal ArticleDOI
Enhancing SIV-specific immunity in vivo by PD-1 blockade
Vijayakumar Velu,Kehmia Titanji,Kehmia Titanji,Baogong Zhu,Sajid Husain,Sajid Husain,Annette Pladevega,Annette Pladevega,Lilin Lai,Lilin Lai,Thomas H. Vanderford,Lakshmi Chennareddi,Lakshmi Chennareddi,Guido Silvestri,Gordon J. Freeman,Rafi Ahmed,Rama Rao Amara,Rama Rao Amara +17 more
TL;DR: In this article, the authors investigated the safety and immune restoration potential of blockade of the co-inhibitory receptor programmed death 1 (PD-1) during chronic simian immunodeficiency virus (SIV) infection in macaques.
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TIM-1 and TIM-4 glycoproteins bind phosphatidylserine and mediate uptake of apoptotic cells.
Norimoto Kobayashi,Piia Karisola,Victor Pena-Cruz,David M. Dorfman,Masahisa Jinushi,Sarah E. Umetsu,Manish J. Butte,Haruo Nagumo,Irene Chernova,Baogong Zhu,Arlene H. Sharpe,Susumu Ito,Glenn Dranoff,Gerardo G. Kaplan,José M. Casasnovas,Dale T. Umetsu,Rosemarie H. DeKruyff,Gordon J. Freeman +17 more
TL;DR: The results show that TIM-4 and TIM-1 are immunologically restricted members of the group of receptors whose recognition of PS is critical for the efficient clearance of apoptotic cells and prevention of autoimmunity.
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Upregulation of CTLA-4 by HIV-specific CD4+ T cells correlates with disease progression and defines a reversible immune dysfunction.
Daniel Kaufmann,Daniel G. Kavanagh,Florencia Pereyra,Florencia Pereyra,John Zaunders,Elizabeth W Mackey,Toshiyuki Miura,Toshiyuki Miura,Sarah Palmer,Mark A. Brockman,Mark A. Brockman,Almas Rathod,Alicja Piechocka-Trocha,Alicja Piechocka-Trocha,Brett Baker,Baogong Zhu,Sylvie Le Gall,Michael T. Waring,Michael T. Waring,Ryan Ahern,Kristin Moss,Anthony D. Kelleher,John M. Coffin,Gordon J. Freeman,Eric S. Rosenberg,Bruce D. Walker,Bruce D. Walker +26 more
TL;DR: It is reported that the inhibitory immunoregulatory receptor CTLA-4 was selectively upregulated in human immunodeficiency virus–specific CD4+ T cells but not CD8- T cells in all categories of HIV-infected subjects evaluated, with the exception of rare people able to control viremia in the absence of antiretroviral therapy.