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Barbara J. Clark
Researcher at University of Louisville
Publications - 78
Citations - 7986
Barbara J. Clark is an academic researcher from University of Louisville. The author has contributed to research in topics: Steroidogenic acute regulatory protein & Leydig cell. The author has an hindex of 37, co-authored 78 publications receiving 7508 citations. Previous affiliations of Barbara J. Clark include Texas Tech University Health Sciences Center.
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Journal ArticleDOI
The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).
TL;DR: It is demonstrated for the first time that expression of the protein in MA-10 cells in the absence of hormone stimulation is sufficient to induce steroid production and it is proposed that this protein is required in the acute regulation of steroidogenesis.
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Regulation of the acute production of steroids in steroidogenic cells.
TL;DR: This chapter will focus on studies designed to elucidate the mechanisms involved in the acute regulation of steroid production in response to hormone stimulation.
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Role of steroidogenic acute regulatory protein in adrenal and gonadal steroidogenesis.
Dong Lin,Teruo Sugawara,Jerome F. Strauss,Barbara J. Clark,Douglas M. Stocco,Paul Saenger,Alan D. Rogol,Walter L. Miller +7 more
TL;DR: In three unrelated individuals with this disorder, steroidogenic acute regulatory protein, which enhances the mitochondrial conversion of cholesterol into pregnenolone, was mutated and nonfunctional, providing genetic evidence that this protein is indispensable normal adrenal and gonadal steroidogenesis.
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Targeted disruption of the mouse gene encoding steroidogenic acute regulatory protein provides insights into congenital lipoid adrenal hyperplasia
Kathleen M. Caron,Shiu Ching Soo,William C. Wetsel,Douglas M. Stocco,Barbara J. Clark,Keith L. Parker,Keith L. Parker +6 more
TL;DR: These StAR knockout mice provide a useful model system in which to determine the mechanisms of StAR's essential roles in adrenocortical and gonadal steroidogenesis and to develop an animal model for the human disorder lipoid congenital adrenal hyperplasia.
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Human steroidogenic acute regulatory protein: functional activity in COS-1 cells, tissue-specific expression, and mapping of the structural gene to 8p11.2 and a pseudogene to chromosome 13
Teruo Sugawara,John A. Holt,Deborah A. Driscoll,Jerome F. Strauss,Dong Lin,Walter L. Miller,David A. Patterson,K P Clancy,Iris Hart,Barbara J. Clark +9 more
TL;DR: Steroidogenic acute regulatory protein (StAR) appears to mediate the rapid increase in pregnenolone synthesis stimulated by tropic hormones and StAR mRNA levels are regulated by cAMP.