B
Barbara Kaltschmidt
Researcher at Bielefeld University
Publications - 150
Citations - 7784
Barbara Kaltschmidt is an academic researcher from Bielefeld University. The author has contributed to research in topics: Stem cell & Neural stem cell. The author has an hindex of 42, co-authored 137 publications receiving 7135 citations. Previous affiliations of Barbara Kaltschmidt include Witten/Herdecke University & University of Freiburg.
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Journal ArticleDOI
Selective Activation of NF-κB by Nerve Growth Factor Through the Neurotrophin Receptor p75
Bruce D. Carter,Christian Kaltschmidt,Barbara Kaltschmidt,Nina Offenhäuser,Renate Böhm-Matthaei,Patrick A. Baeuerle,Yves-Alain Barde +6 more
TL;DR: In the absence of TrkA, NGF binding to p75NTR activated the transcription factor nuclear factor kappa B (NF-κB) in rat Schwann cells, and the effect was selective for NGF; NF-κBs was not activated by BDNF or NT-3.
Journal ArticleDOI
Transcription factor NF-κB is activated in primary neurons by amyloid β peptides and in neurons surrounding early plaques from patients with Alzheimer disease
TL;DR: The data suggest that the aberrant gene expression in diseased nervous tissue is at least in part due to Aβ-induced activation of NF-κB, a potent immediate–early transcriptional regulator of numerous proinflammatory genes.
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Constitutive NF-kappa B activity in neurons.
TL;DR: Activated NF-kappa B in the brain is likely to participate in normal brain function and to reflect a distinct state of neuronal activity or differentiation, an observation potentially relevant for the etiology of the AIDS dementia complex caused by HIV infection of the central nervous system.
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NF-kappaB in the nervous system.
TL;DR: Inhibition of NF-kappaB in glia might ameliorate disease, whereas activation in neurons might enhance memory, and this review focuses on results produced by the analysis of genetic models.
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Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons.
TL;DR: It is reported that brief treatments with kainate or high potassium strongly activated NF-kappa B in granule cells from rat cerebellum, and this may explain the kainates-induced cell surface expression of major histocompatibility complex class I molecules, which are encoded by genes known to be controlled by NF- kappa B.