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Barbara S. Kirschner
Researcher at University of Chicago
Publications - 131
Citations - 14457
Barbara S. Kirschner is an academic researcher from University of Chicago. The author has contributed to research in topics: Inflammatory bowel disease & Crohn's disease. The author has an hindex of 46, co-authored 129 publications receiving 13523 citations. Previous affiliations of Barbara S. Kirschner include Baylor College of Medicine & Johns Hopkins University.
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Journal ArticleDOI
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
Yasunori Ogura,Denise K. Bonen,Naohiro Inohara,Dan L. Nicolae,Felicia F. Chen,Richard Ramos,Heidi M. Britton,Thomas M. Moran,Reda Karaliuskas,Richard H. Duerr,Jean-Paul Achkar,Steven R. Brant,Theodore M. Bayless,Barbara S. Kirschner,Stephen B. Hanauer,Gabriel Núñez,Judy H. Cho +16 more
TL;DR: It is shown that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease, and a link between an innate immune response to bacterial components and development of disease is suggested.
Journal Article
Development and validation of a pediatric Crohn's disease activity index.
Jeffrey S. Hyams,G. D. Ferry,Francine S. Mandel,Joyce D. Gryboski,Phillip M. Kibort,Barbara S. Kirschner,Anne M. Griffiths,Aubrey J. Katz,Richard J. Grand,John T. Boyle +9 more
TL;DR: This paper used clinical and laboratory observations of 133 children and adolescents with Crohn's disease to validate an index of severity of illness previously developed by a group of senior pediatric gastroenterologists at a research forum in April 1990.
Journal ArticleDOI
Development and Validation of a Pediatric Crohnʼs Disease Activity Index
Jeffrey S. Hyams,George D. Ferry,Francine S. Mandel,Joyce D. Gryboski,Phillip M. Kibort,Barbara S. Kirschner,Anne M. Griffiths,Aubrey J. Katz,Richard J. Grand,John T. Boyle,William M. Michener,Joseph Levy,Martin Lesser +12 more
TL;DR: It is proposed that the PCDAI could be used in multicenter projects to facilitate patient stratification by disease severity and that longitudinalPCDAI scores might provide a numerical measure of response to therapeutic regimens.
Journal ArticleDOI
Children with early-onset inflammatory bowel disease (IBD): analysis of a pediatric IBD consortium registry.
Melvin B. Heyman,Barbara S. Kirschner,Benjamin D. Gold,George D. Ferry,Robert N. Baldassano,Stanley A. Cohen,Harland S. Winter,Patricia Fain,Chris S. King,Terry J. Smith,Hashem B. El-Serag +10 more
TL;DR: This demographically diverse pediatric IBD cohort revealed age-related variation in the distribution of IBD phenotype, with a high prevalence of isolated colonic disease in young children.
Journal ArticleDOI
Common variants at five new loci associated with early-onset inflammatory bowel disease.
Marcin Imielinski,Robert N. Baldassano,Anne M. Griffiths,Richard K Russell,Vito Annese,Marla Dubinsky,Subra Kugathasan,Jonathan P. Bradfield,Thomas D. Walters,Patrick M. A. Sleiman,Cecilia E. Kim,Aleixo M. Muise,Kai Wang,Joseph T. Glessner,Shehzad Ahmed Saeed,Haitao Zhang,Edward C. Frackelton,Cuiping Hou,James H. Flory,George Otieno,Rosetta M. Chiavacci,Robert W. Grundmeier,Massimo Castro,Anna Latiano,Bruno Dallapiccola,Joanne M. Stempak,Debra J. Abrams,Kent D. Taylor,Dermot P.B. McGovern,Melvin B. Heyman,George D. Ferry,Barbara S. Kirschner,Jessica T. Lee,Jonah Essers,Richard J. Grand,Michael C. Stephens,Arie Levine,David A. Piccoli,Johan Van Limbergen,Salvatore Cucchiara,Dimitri S. Monos,Stephen L. Guthery,Lee A. Denson,David C. Wilson,Struan F.A. Grant,Mark J. Daly,Mark S. Silverberg,Jack Satsangi,Hakon Hakonarson +48 more
TL;DR: The results of a genome-wide association study in early-onset IBD involving 3,426 affected individuals and 11,963 genetically matched controls recruited through international collaborations in Europe and North America are reported, thereby extending the results from a previous study of 1,011 individuals with early-onset IBD.