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Barbara Shih

Researcher at University of Edinburgh

Publications -  48
Citations -  2472

Barbara Shih is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Population & Keloid. The author has an hindex of 18, co-authored 43 publications receiving 1514 citations. Previous affiliations of Barbara Shih include Salford Royal NHS Foundation Trust & Manchester Academic Health Science Centre.

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Genetic mechanisms of critical illness in Covid-19.

Erola Pairo-Castineira, +1449 more
- 04 Mar 2021 - 
TL;DR: The GenOMICC (Genetics Of Mortality In Critical Care) genome-wide association study in 2244 critically ill Covid-19 patients from 208 UK intensive care units is reported, finding evidence in support of a causal link from low expression of IFNAR2, and high expression of TYK2, to life-threatening disease.
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Genetics of keloid scarring

TL;DR: A varied inheritance pattern in KD is indicated (predominantly autosomal dominant), linkage loci (chromosomes 2q23 and 7p11), several human leukocyte antigen alleles (HLA-DRB1*15, HLA-DQA1*0104), negative candidate gene case–control association studies and at least 25 dysregulated genes reported in multiple microarray studies.
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Molecular dissection of abnormal wound healing processes resulting in keloid disease.

TL;DR: A detailed account of individual phases of the healing process and how they may potentially be implicated in aberrant raised scar formation is presented, which may help in clarifying the mechanisms involved in keloid disease pathogenesis.
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Scientific understanding and clinical management of Dupuytren disease

TL;DR: A detailed update of the scientific understanding of Dupuytren disease and its clinical management is provided, with perspectives on emerging research and therapy.
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Immune cell gene signatures for profiling the microenvironment of solid tumors

TL;DR: The utility of ImSig is demonstrated through the stratification of melanoma patients into subgroups of prognostic significance and the identification of immune cells with the use of single-cell RNA-sequencing data derived from tumors.