Author
Barnabas Wilson
Bio: Barnabas Wilson is an academic researcher from Central Tuber Crops Research Institute. The author has contributed to research in topics: Drug carrier & Nanomedicine. The author has an hindex of 16, co-authored 22 publications receiving 1305 citations.
Topics: Drug carrier, Nanomedicine, Medicine, Chemistry, Coronavirus
Papers
More filters
TL;DR: It is demonstrated that the brain concentration of intravenously injected rivastigmine can be enhanced over 3.82 fold by binding to poly(n-butylcyanoacrylate) nanoparticles coated with 1% nonionic surfactant polysorbate 80.
319 citations
TL;DR: It is demonstrated that the brain concentration of intravenously injected tacrine can be enhanced by binding to poly(n-butylcyanoacrylate) nanoparticles, coated with 1% the nonionic surfactant polysorbate 80.
238 citations
TL;DR: Chitosan nanoparticles are investigated in a pre-clinical study as an optimized delivery system for tacrin, a drug with potential significance in Alzheimer's disease and showed optimal pharmacokinetic characteristics in a rat model.
218 citations
TL;DR: The findings support the use of Curcuma zedoaria tubers in traditional medicine for the treatment of bacterial and fungal infections and the first report of the antimicrobial properties ofCurcuma malabarica.
147 citations
TL;DR: Nanomedicines still impose many challenges to researchers to obtain the maximum benefits for patients during diagnosis and therapy, and a forthcoming major challenge among the developmental stages of nano medicine is industrial scale-up (large scale industrial production).
63 citations
Cited by
More filters
TL;DR: Various nanostructures, including liposomes, polymers, dendrimers, silicon or carbon materials, and magnetic nanoparticles, have been tested as carriers in drug delivery systems and their connections with drugs are analyzed.
1,007 citations
TL;DR: The delivery of drugs, which usually are not able to cross the BBB, into the brain was confirmed by the biodistribution studies and pharmacological assays in rodents, and the presence of nanoparticles in the brain parenchyma was visualized by electron microscopy, suggesting that this technology holds great promise for non-invasive therapy of the CNS diseases.
558 citations
TL;DR: In this review, the unique properties of brain microvascular endothelial cells and intercellular junctions are examined and some of the experimental approaches that can be used to monitor BBB properties and function in a variety of conditions and have allowed recent advances in BBB knowledge are summarized.
527 citations
TL;DR: This review summarizes the various nanocarriers developed so far in the literature for nanotheranostics, which include polymer conjugations, dendrimers, micelles, liposomes, metal and inorganic nanoparticles, carbon nanotubes, and nanoparticles of biodegradable polymers for sustained, controlled and targeted co-delivery of diagnostic and therapeutic agents for better theranostic effects with fewer side effects.
Abstract: Nanotheranostics is to apply and further develop nanomedicine strategies for advanced theranostics. This review summarizes the various nanocarriers developed so far in the literature for nanotheranostics, which include polymer conjugations, dendrimers, micelles, liposomes, metal and inorganic nanoparticles, carbon nanotubes, and nanoparticles of biodegradable polymers for sustained, controlled and targeted co-delivery of diagnostic and therapeutic agents for better theranostic effects with fewer side effects. The theranostic nanomedicine can achieve systemic circulation, evade host defenses and deliver the drug and diagnostic agents at the targeted site to diagnose and treat the disease at cellular and molecular level. The therapeutic and diagnostic agents are formulated in nanomedicine as a single theranostic platform, which can then be further conjugated to biological ligand for targeting. Nanotheranostics can also promote stimuli-responsive release, synergetic and combinatory therapy, siRNA co-delivery, multimodality therapies, oral delivery, delivery across the blood-brain barrier as well as escape from intracellular autophagy. The fruition of nanotheranostics will be able to provide personalized therapy with bright prognosis, which makes even the fatal diseases curable or at least treatable at the earliest stage.
475 citations
TL;DR: Carvacrol-loaded chitosan nanoparticles showed antimicrobial activity against Staphylococcus aureus, Bacillus cereus and Escherichia coli with an MIC of 0.257 mg/mL and the release rate was superior in an acidic medium to either alkaline or neutral media, respectively.
456 citations