B
Bart Cuypers
Researcher at University of Antwerp
Publications - 58
Citations - 1164
Bart Cuypers is an academic researcher from University of Antwerp. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 16, co-authored 44 publications receiving 792 citations. Previous affiliations of Bart Cuypers include Institute of Tropical Medicine Antwerp.
Papers
More filters
Journal ArticleDOI
Modulation of Aneuploidy in Leishmania donovani during Adaptation to Different In Vitro and In Vivo Environments and Its Impact on Gene Expression.
Franck Dumetz,Hideo Imamura,Mandy Sanders,Veronika Seblova,Jitka Myskova,Pascale Pescher,Manu Vanaerschot,Conor J. Meehan,Bart Cuypers,Bart Cuypers,G. De Muylder,Gerald F. Späth,Giovanni Bussotti,J. R. Vermeesch,Matthew Berriman,James Cotton,Petr Volf,Jean-Claude Dujardin,Jean-Claude Dujardin,Malgorzata A. Domagalska +19 more
TL;DR: The whole genomes and transcriptomes of Leishmania donovani strains throughout their adaptation to in vivo conditions mimicking natural vertebrate and invertebrate host environments are sequenced to allow studies of the impact of aneuploidy on molecular adaptations and cellular fitness.
Journal ArticleDOI
Evolutionary genomics of epidemic visceral leishmaniasis in the Indian subcontinent
Hideo Imamura,Tim Downing,Tim Downing,Frederik Van den Broeck,Mandy Sanders,Suman Rijal,Shyam Sundar,An Mannaert,Manu Vanaerschot,Maya Berg,Géraldine De Muylder,Franck Dumetz,Bart Cuypers,Ilse Maes,Malgorzata A. Domagalska,Saskia Decuypere,Saskia Decuypere,Keshav Rai,Surendra Uranw,Narayan Raj Bhattarai,Basudha Khanal,Vijay Kumar Prajapati,Smriti Sharma,Olivia Stark,Gabriele Schönian,Harry P. de Koning,Luca Settimo,Luca Settimo,Benoit Vanhollebeke,Syamal Roy,Bart Ostyn,Marleen Boelaert,Louis Maes,Matthew Berriman,Jean-Claude Dujardin,Jean-Claude Dujardin,James Cotton +36 more
TL;DR: The results reveal the complexity of L. donovani evolution in the ISC in response to drug treatment, and find evidence of genetic exchange between ISC populations, and show that the mutation in LdAQP1 has spread by recombination.
Journal ArticleDOI
Genomic and Molecular Characterization of Miltefosine Resistance in Leishmania infantum Strains with Either Natural or Acquired Resistance through Experimental Selection of Intracellular Amastigotes.
Annelies Mondelaers,María P. Sánchez-Cañete,Sarah Hendrickx,Eline Eberhardt,Raquel García-Hernández,Laurence Lachaud,James Cotton,Mandy Sanders,Bart Cuypers,Hideo Imamura,Jean-Claude Dujardin,Peter Delputte,Paul Cos,Guy Caljon,Francisco Gamarro,Santiago Castanys,Louis Maes +16 more
TL;DR: A defective import machinery through inactivation of the LiMT/LiRos3 protein complex as the main mechanism for MIL-resistance also in intracellular amastigotes is confirmed and corroborate the pivotal role of theLiMT/ LiRos3 complex in resistance towards MIL.
Journal ArticleDOI
A community resource for paired genomic and metabolomic data mining
Michelle Schorn,Stefan Verhoeven,Lars Ridder,Florian Huber,Deepa D. Acharya,Alexander A. Aksenov,Gajender Aleti,Jamshid Amiri Moghaddam,Allegra T. Aron,Saefuddin Aziz,Saefuddin Aziz,Anelize Bauermeister,Anelize Bauermeister,Katherine D. Bauman,Martin Baunach,Christine Beemelmanns,J. Michael Beman,María Victoria Berlanga-Clavero,Alex A. Blacutt,Helge B. Bode,Anne Boullie,Asker Daniel Brejnrod,Tim S. Bugni,Alexandra Calteau,Liu Cao,Víctor J. Carrión,Raquel Castelo-Branco,Raquel Castelo-Branco,Shaurya Chanana,Alexander B. Chase,Marc G. Chevrette,Letícia V. Costa-Lotufo,Jason M. Crawford,Cameron R. Currie,Cameron R. Currie,Bart Cuypers,Bart Cuypers,Tam Dang,Tristan de Rond,Alyssa M. Demko,Elke Dittmann,Chao Du,Christopher Drozd,Jean-Claude Dujardin,Rachel J. Dutton,Anna Edlund,Anna Edlund,David P. Fewer,Neha Garg,Julia M. Gauglitz,Emily C. Gentry,Lena Gerwick,Evgenia Glukhov,Harald Gross,Muriel Gugger,Dulce G. Guillén Matus,Eric J. N. Helfrich,Benjamin-Florian Hempel,Benjamin-Florian Hempel,Jae Seoun Hur,Marianna Iorio,Paul R. Jensen,Kyo Bin Kang,Leonard Kaysser,Neil L. Kelleher,Chung Sub Kim,Chung Sub Kim,Ki-Hyun Kim,Irina Koester,Gabriele M. König,Tiago Leao,Tiago Leao,Seoung Rak Lee,Seoung Rak Lee,Yi Yuan Lee,Xuanji Li,Jessica C. Little,Katherine N. Maloney,Daniel Männle,Christian Martin H,Andrew C. McAvoy,Willam W. Metcalf,Hosein Mohimani,Carlos Molina-Santiago,Bradley S. Moore,Bradley S. Moore,Michael W. Mullowney,Mitchell N. Muskat,Louis-Félix Nothias,Ellis C. O’Neill,Elizabeth I. Parkinson,Daniel Petras,Daniel Petras,Jörn Piel,Emily C Pierce,Karine Pires,Raphael Reher,Diego Romero,M. Caroline Roper,Michael J. Rust,Hamada Saad,Carmen Saenz,Laura M. Sanchez,Søren J. Sørensen,Margherita Sosio,Roderich D. Süssmuth,Douglas Sweeney,Kapil Tahlan,Regan J. Thomson,Nicholas J. Tobias,Amaro E. Trindade-Silva,Gilles P. van Wezel,Mingxun Wang,Kelly C. Weldon,Kelly C. Weldon,Fan Zhang,Nadine Ziemert,Katherine R. Duncan,Max Crüsemann,Simon Rogers,Pieter C. Dorrestein,Marnix H. Medema,Justin J. J. van der Hooft +122 more
TL;DR: The Paired Omics Data Platform as mentioned in this paper is a community initiative to systematically document links between metabolome and (meta)genome data, aiding identification of natural product biosynthetic origins and metabolite structures.
Journal ArticleDOI
Relapse after Treatment with Miltefosine for Visceral Leishmaniasis Is Associated with Increased Infectivity of the Infecting Leishmania donovani Strain
Keshav Rai,Keshav Rai,Bart Cuypers,Narayan Raj Bhattarai,Surendra Uranw,Maya Berg,Bart Ostyn,Jean-Claude Dujardin,Jean-Claude Dujardin,Suman Rijal,Manu Vanaerschot +10 more
TL;DR: An increased infectivity of the parasite is associated with miltefosine relapse of visceral leishmaniasis patients, and this challenges the current view of Leishmania drug susceptibility being the biggest parasitic factor that contributes to treatment failure in leish maniasis.