Bart Roman

TL;DR: This paper explored the opportunities for chemists at the interface between biologics and small molecule-based products and provided concrete examples by zooming in on the area of post-translational protein modification.

TL;DR: This novel class of brevianamide F analogues possess interesting breast cancer resistance protein inhibitory activity and several derivatives of the thus obtained α-chloroamine were synthesized by substitution of the chlorine atom.

TL;DR: In this paper, a continuous flow synthesis of a model phenothiazine antipsychotic using 3-chloropropionyl chloride as a central building block is presented, with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.

TL;DR: In this paper, the compatibility of a number of protection and activation strategies with the 1,2-addition of a variety of O-, N-, S-, and C-nucleophiles to ferulic acid is evaluated.

TL;DR: In this paper, the authors demonstrate that nanoparticle-sensitized laser induced photoporation forms an attractive alternative to efficiently deliver the contrast agent gadobutrol into the cytosol of both HeLa and SK-OV-3 IP1 cells.