B
Bart Vanhaesebroeck
Researcher at University College London
Publications - 264
Citations - 32056
Bart Vanhaesebroeck is an academic researcher from University College London. The author has contributed to research in topics: PI3K/AKT/mTOR pathway & Signal transduction. The author has an hindex of 79, co-authored 248 publications receiving 29549 citations. Previous affiliations of Bart Vanhaesebroeck include Ludwig Institute for Cancer Research & Queen Mary University of London.
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Journal ArticleDOI
Phosphatidylinositol-3-oh kinase as a direct target of ras
Pablo Rodriguez-Viciana,Patricia H. Warne,Ritu Dhand,Bart Vanhaesebroeck,Ivan Gout,Michael J. Fry,Michael D. Waterfield,Michael D. Waterfield,Julian Downward +8 more
TL;DR: In vivo, dominant negative Ras mutant N17 inhibits growth factor induced production of 3′ hosphorylated phosphoinositides in PC12 cells, and transfection of Ras, but not Raf, into COS cells results in a large elevation in the level of these lipids.
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The PI3K-PDK1 connection: more than just a road to PKB.
TL;DR: The mechanism by which PKB is activated and the downstream actions of this multifunctional kinase are reviewed, as well as the evidence that PDK1 may be involved in the activation of protein kinases other than PKB, and the possibility that some of the currently postulated PKB substrates targets might in fact be phosphorylated byPDK1-regulated kinasesother than P KB.
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Synthesis and Function of 3-Phosphorylated Inositol Lipids
Bart Vanhaesebroeck,Sally J. Leevers,Khatereh Ahmadi,John F. Timms,Roy Katso,Paul C. Driscoll,Rudiger Woscholski,Peter J. Parker,Michael D. Waterfield +8 more
TL;DR: This review is focused on the 3-phosphoinositide lipids, the synthesis of which is acutely triggered by extracellular stimuli, the enzymes responsible for their synthesis and metabolism, and their cell biological roles.
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The emerging mechanisms of isoform-specific PI3K signalling
TL;DR: A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.
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Phosphoinositide 3-kinases: a conserved family of signal transducers.
TL;DR: Phosphoinositide 3-kinases generate lipids that are implicated in receptor-stimulated signalling and in the regulation of membrane traffic and their potential signalling pathways have been elucidated and PI3K function is now being characterised in several model organisms.