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Bastien Touquet

Bio: Bastien Touquet is an academic researcher from École pratique des hautes études. The author has contributed to research in topics: Synaptic fatigue & AMPA receptor. The author has an hindex of 1, co-authored 1 publications receiving 782 citations.

Papers
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Journal ArticleDOI
19 May 2006-Cell
TL;DR: The degree of astrocytic coverage of neurons governs the level of glycine site occupancy on the NMDA receptor, thereby affecting their availability for activation and thus the activity dependence of long-term synaptic changes.

836 citations

Journal ArticleDOI
TL;DR: To characterize a recently identified basal pole marker named BCC7 with respect to the posterior myosin J and myos in C motors, conventional biochemistry as well as advanced proteomic and in silico analysis are used in conjunction with live and super resolution microscopy of transgenic fluorescent tachyzoites.
Abstract: T. gondii is a eukaryotic parasite that has evolved a stage called tachyzoite which multiplies in host cells by producing two daughter cells internally. These nascent tachyzoites bud off their mother and repeat the division process until the expanding progenies escape to settle and multiply in other host cells. Over these intra- and extra-cellular phases, the tachyzoite maintains an essential apicobasal polarity that emerges through a unique bidirectional budding process of the elongating cells. This process requires the assembly of several molecular complexes that, at the nascent pole, encompass structural and myosin motor elements. To characterize a recently identified basal pole marker named BCC7 with respect to the posterior myosin J and myosin C motors, we used conventional biochemistry as well as advanced proteomic and in silico analysis in conjunction with live and super resolution microscopy of transgenic fluorescent tachyzoites. We document that BCC7 forms a ribbed ring below which myosin C motor entities distribute regularly. In addition, we identified—among 13 BCC7 putative partners—two novel and five known members of the inner membrane complex (IMC) family which ends at the apical side of the ring. Therefore, BCC7 could assist the stabilization of the IMC plaques and contribute to the parasite biomechanical properties.

3 citations


Cited by
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Journal ArticleDOI
TL;DR: This review discusses International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.
Abstract: The mammalian ionotropic glutamate receptor family encodes 18 gene products that coassemble to form ligand-gated ion channels containing an agonist recognition site, a transmembrane ion permeation pathway, and gating elements that couple agonist-induced conformational changes to the opening or closing of the permeation pore. Glutamate receptors mediate fast excitatory synaptic transmission in the central nervous system and are localized on neuronal and non-neuronal cells. These receptors regulate a broad spectrum of processes in the brain, spinal cord, retina, and peripheral nervous system. Glutamate receptors are postulated to play important roles in numerous neurological diseases and have attracted intense scrutiny. The description of glutamate receptor structure, including its transmembrane elements, reveals a complex assembly of multiple semiautonomous extracellular domains linked to a pore-forming element with striking resemblance to an inverted potassium channel. In this review we discuss International Union of Basic and Clinical Pharmacology glutamate receptor nomenclature, structure, assembly, accessory subunits, interacting proteins, gene expression and translation, post-translational modifications, agonist and antagonist pharmacology, allosteric modulation, mechanisms of gating and permeation, roles in normal physiological function, as well as the potential therapeutic use of pharmacological agents acting at glutamate receptors.

3,044 citations

Journal ArticleDOI
TL;DR: There is an emerging view, which is reviewed herein, in which brain function actually arises from the coordinated activity of a network comprising both neurons and glia, rather than the classically accepted paradigm that brain function results exclusively from neuronal activity.

1,481 citations

Journal ArticleDOI
04 Mar 2011-Cell
TL;DR: It is concluded that astrocyte-neuron lactate transport is required for long-term memory formation, suggesting that lactate import into neurons is necessary for long -term memory.

1,255 citations

Journal ArticleDOI
TL;DR: The application of subcellular imaging of Ca2+ signaling to astrocytes now provides functional data to support this structural notion that both excitatory and inhibitory signals provided by the same glial cell act in concert to regulate neuronal function.
Abstract: From a structural perspective, the predominant glial cell of the central nervous system, the astrocyte, is positioned to regulate synaptic transmission and neurovascular coupling: the processes of ...

1,251 citations

Journal ArticleDOI
06 Nov 2008-Neuron
TL;DR: It is argued that until the roles of nonneuronal cells are more fully understood and considered, neurobiology as a whole will progress only slowly.

1,226 citations