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Béatrice Plougastel
Researcher at Washington University in St. Louis
Publications - 20
Citations - 5170
Béatrice Plougastel is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Gene & Chromosome 22. The author has an hindex of 12, co-authored 20 publications receiving 4934 citations. Previous affiliations of Béatrice Plougastel include Curie Institute & French Institute of Health and Medical Research.
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Journal ArticleDOI
Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours
Olivier Delattre,Jessica Zucman,Béatrice Plougastel,Chantal Desmaze,Thomas Melot,Martine Peter,Heinrich Kovar,Isabelle Joubert,Pieter J. de Jong,Guy A. Rouleau,Alain Aurias,Gilles Thomas +11 more
TL;DR: Phylogenetically conserved restriction fragments in the vicinity of EWSR1 and EWSR2, the genomic regions where the breakpoints of chromosome 22 and chromosome 11 are, respectively, have allowed identification of transcribed sequences from these regions and has indicated that a hybrid transcript might be generated by the translocation.
Journal ArticleDOI
Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2
Guy A. Rouleau,P. Merel,Mohini Lutchman,Marc Sanson,Marc Sanson,Jessica Zucman,Claude Marineau,Khê Hoang-Xuan,S. Demczuk,Chantal Desmaze,Béatrice Plougastel,Stefan M. Pulst,Gilbert M. Lenoir,E. K. Bijlsma,Raimund Fashold,Jan P. Dumanski,Pieter J. de Jong,Dilys M. Parry,Roswell Eldrige,Alain Aurias,Olivier Delattre,Gilles Thomas +21 more
TL;DR: The deduced product has homology with proteins at the plasma membrane and cytoskeleton Interface, a previously unknown site of action of tumour suppressor genes in humans.
Journal ArticleDOI
Immune functions encoded by the natural killer gene complex.
TL;DR: The properties of NKC-encoded receptors are reviewed, and a genomic and conceptual framework for an insight into NK-cell function and biology is provided.
Journal ArticleDOI
Combinatorial generation of variable fusion proteins in the Ewing family of tumours.
J Zucman,Thomas Melot,C Desmaze,J Ghysdael,Béatrice Plougastel,M Peter,J M Zucker,Timothy J. Triche,Denise Sheer,C Turc-Carel +9 more
TL;DR: In Ewing's sarcoma and malignant melanoma of soft parts, translocations of band 22q12 to chromosome 11 and 12 result in the fusion of EWS with the transcription factors FLI‐1 and ATF1, respectively, suggesting that oncogenic conversion is achieved by the linking of the two domains with no marked constraint on the connecting peptide.
Journal ArticleDOI
Cloning and characterization of the Ewing's sarcoma and peripheral neuroepithelioma t(11;22) translocation breakpoints.
Jessica Zucman,Olivier Delattre,Chantal Desmaze,Béatrice Plougastel,Isabelle Joubert,Thomas Melot,Martine Peter,Pieter J. de Jong,Guy A. Rouleau,Alain Aurias,Gilles Thomas +10 more
TL;DR: No evidence was found of any specific difference in the position of ES and PN translocation breakpoints, and the molecular characterization of the translocated breakpoints showed that most chromosome 22 breakpoints are clustered within a small, 2 kb region.