Showing papers by "Beatriz S. Parajón-Costa published in 2019"
TL;DR: In this paper, the tridentate N-acyhydrazone derived from 4-hydroxy-benzohydrazide and 2-hydroxyl-3-methoxybenzaldehyde (H2L) was synthesized and characterized in the solid state and in solution by spectroscopic (FTIR, Ra, UV-vis, EPR) methods.
34 citations
TL;DR: In this article, an oxidovanadium(IV) complex (VOL2) was obtained from the interaction of the vanadyl ion with a ligand, obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine.
Abstract: From the interaction of the vanadyl ion with a ligand (HL), obtained by the condensation reaction of o-vanillin and 2-thiophenemethylamine, an oxidovanadium(IV) complex (VOL2) was obtained. It was characterized by spectroscopic techniques, including solid state FTIR, Raman, EPR and diffuse reflectance, and UV-vis and EPR, in solution. Its thermal behavior was analyzed by means of TGA and DTA. Theoretical studies based on DFT computational methods aided in the interpretation and assignment of spectroscopic data. Cytotoxicity assays (48 h) against bone cancer cells (MG-63, IC50 = 50.4 ± 8.7), breast cancer cells (MCF-7, IC50 = 42.3 ± 4.7), (MDA-MB-231, IC50 = 29.0 ± 1.7) and a normal fibroblast (L929, IC50 = 71.0 ± 3.5) demonstrated the enhancement of the effectiveness and selectivity of the complex as compared with both the ligand and the free metal ion. Besides, the compound inhibits cell migration, increases ROS levels and facilitates apoptosis. On a whole, these results show the main mechanisms of the deleterious effects of [VOL2] in a triple negative breast cancer cell line (MDA-MB-231), demonstrating that this complex is a promising therapeutic agent for this kind of breast cancer.
13 citations
TL;DR: The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure and optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study.
Abstract: The complex bis(4,7-dimethyl-1,10-phenantroline)sulfatooxidovanadium(IV), commonly known as Metvan, was prepared using a known synthetic procedure. Its optimized molecular structure was obtained by DFT calculations, as it was impossible to grow single crystals adequate for a crystallographic study. The complex was also characterized by a detailed analysis of its infrared spectrum, supported by the theoretical calculations, and also by some data derived from its Raman spectrum. In addition, cytotoxicity studies were performed using human osteosarcoma (MG-63) and human colorectal adenocarcinoma (HT-29) cell lines. The results show that Metvan impaired cell viability of both cancer cell lines in a low concentration range (0.25–5.0 μM).
11 citations
TL;DR: The mixed cation diphosphate of composition NH4FeP2O7 has been prepared by heating of adequate mixtures of NH4(H2PO4) and Fe(NO3)3⋅9H2O in concentrated phosphoric acid, and characterized by X-ray powder diffractometry as discussed by the authors.