scispace - formally typeset
Search or ask a question
Author

Beatriz S. Parajón-Costa

Bio: Beatriz S. Parajón-Costa is an academic researcher from National University of La Plata. The author has contributed to research in topics: Crystal structure & Cyclic voltammetry. The author has an hindex of 17, co-authored 53 publications receiving 875 citations. Previous affiliations of Beatriz S. Parajón-Costa include National Scientific and Technical Research Council.


Papers
More filters
Journal ArticleDOI
TL;DR: Results showed that structural modifications on the semicarbazone moiety could have a significant effect on the anti-tumor activity of the vanadium complexes, and no apparent correlation could be demonstrated between reduction potentials of the complexes and their anti-Tumor activities.

113 citations

Journal ArticleDOI
TL;DR: The binuclear vanadium vanadium (V) compound was determined by X-ray diffraction methods as mentioned in this paper, and the structure of the vanadium compound was analyzed using the infrared and Raman spectra.

68 citations

Journal ArticleDOI
TL;DR: The data strongly suggest that trypanocidal action of the complexes could mainly rely on the inhibition of the parasite-specific enzyme NADH-fumarate reductase.
Abstract: In the search for new therapeutic tools against Chagas disease (American trypanosomiasis) palladium and platinum complexes of the bioactive ligand pyridine-2-thiol N-oxide were exhaustively characterized and evaluated in vitro. Both complexes showed high in vitro growth inhibition activity (IC(50) values in the nanomolar range) against Trypanosoma cruzi, the causative agent of the disease. They were 39-115 times more active than the antitrypanosomal drug Nifurtimox. The palladium complex showed an approximately threefold enhancement of the activity compared with the parent compound. In addition, owing to their low unspecific cytotoxicity on mammalian cells, the complexes showed a highly selective antiparasite activity. To get an insight into the mechanism of action of these compounds, DNA, redox metabolism (intraparasite free-radical production) and two parasite-specific enzymes absent in the host, namely, trypanothione reductase and NADH-fumarate reductase, were evaluated as potential parasite targets. Additionally, the effect of metal coordination on the free radical scavenger capacity previously reported for the free ligand was studied. All the data strongly suggest that trypanocidal action of the complexes could mainly rely on the inhibition of the parasite-specific enzyme NADH-fumarate reductase.

57 citations

Journal ArticleDOI
TL;DR: Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against T. cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels.

55 citations

Journal ArticleDOI
TL;DR: The crystal structures of Na[Cr(dipic)2]· 2H2O (1) and [Cr(Dipic)(phen)Cl]· 1/2H 2O (2), dipic=dipicolinate, phen = 1,10-phenantroline, were determined.

47 citations


Cited by
More filters
Journal ArticleDOI
TL;DR: Ruthenium-based anticancer chemotherapies are making significant advances in clinical trials as discussed by the authors. But the focus has been on coordination complexes, and mechanisms such as "activation by reduction" and "transferrin-targeted delivery" have been proposed to account for the excellent cytotoxicity and low general toxicity of these complexes.
Abstract: Ruthenium-based anticancer chemotherapies are making significant advances in clinical trials. Until recently, the focus has been on coordination complexes, and mechanisms such as "activation by reduction" and "transferrin-targeted delivery" have been proposed to account for the excellent cytotoxicity and low general toxicity of these complexes. More recently organoruthenium compounds, which to some extent appear not to follow the established rules, have started to be investigated. Despite such differences, similar activities between certain coordination and organometallic compounds suggest similar modes of action are present. DNA, the classic target, is believed to be the dominant mechanism for cytotoxicity with certain ruthenium drugs, while with others, non-classical targets are thought to be more important. In this article we describe these features and show how both ruthenium coordination complexes and organoruthenium compounds represent an ideal scaffold for further drug design and optimisation.

572 citations

Journal ArticleDOI
TL;DR: If the potential opportunities of the Cu-NSAIDs are to be completely realized, a mechanistic understanding and delineation of their in vivo and in vitro pharmacological activity is fundamental, along with further characterization of their pharmacokinetic/pharmacodynamic disposition.

482 citations

Journal ArticleDOI
TL;DR: This review provides an overview of metal-based anticancer drugs and drug candidates, focusing on metal complexes that can be activated in the reducing environment of cancer cells, thus serving as prodrugs.

430 citations

Journal ArticleDOI
TL;DR: In this article, the authors discuss the modes of coordination of oligopeptides by Cu(II) and Ni(II), and special attention is given to two general classes of peptides.

411 citations

Journal ArticleDOI
TL;DR: This work reviews the medicinal applications proposed for vanadium compounds with particular emphasis on the more recent publications and concludes that the potential ofVanadium compounds to treat type 2 diabetes is still an open question and therapies using vanadium compound for e.g. antitumor and anti-parasitic related diseases remain promising.

373 citations