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Belinda Phipson
Researcher at Royal Children's Hospital
Publications - 58
Citations - 28640
Belinda Phipson is an academic researcher from Royal Children's Hospital. The author has contributed to research in topics: Bioconductor & Progenitor cell. The author has an hindex of 27, co-authored 51 publications receiving 18485 citations. Previous affiliations of Belinda Phipson include University of Melbourne & Walter and Eliza Hall Institute of Medical Research.
Papers
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Journal ArticleDOI
limma powers differential expression analyses for RNA-sequencing and microarray studies
Matthew E. Ritchie,Belinda Phipson,Di Wu,Yifang Hu,Charity W. Law,Wei Shi,Gordon K. Smyth,Gordon K. Smyth +7 more
TL;DR: The philosophy and design of the limma package is reviewed, summarizing both new and historical features, with an emphasis on recent enhancements and features that have not been previously described.
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Robust hyperparameter estimation protects against hypervariable genes and improves power to detect differential expression
TL;DR: The robust empirical Bayes (RB) algorithm as mentioned in this paper improves the robust differential expression tests by robustifying the hyperparameter estimation procedure, which has the double benefit of reducing the chance that hypervariable genes will be spuriously identified as DE while increasing statistical power for the main body of genes.
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Splatter: simulation of single-cell RNA sequencing data
TL;DR: The Splatter Bioconductor package is presented for simple, reproducible, and well-documented simulation of scRNA-seq data and provides an interface to multiple simulation methods including Splatter, the authors' own simulation, based on a gamma-Poisson distribution.
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missMethyl: an R package for analyzing data from Illumina’s HumanMethylation450 platform
TL;DR: The missMethyl package as mentioned in this paper is an R package with a suite of tools for performing normalization, removal of unwanted variation in differential methylation analysis, differential variability testing and gene set analysis for the Illumina HumanMethylation450 BeadChip.
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Pro-Inflammatory CD11c+CD206+ Adipose Tissue Macrophages Are Associated With Insulin Resistance in Human Obesity
John M. Wentworth,Gaetano Naselli,Wendy A. Brown,Lisa Doyle,Belinda Phipson,Gordon K. Smyth,Martin Wabitsch,Paul E. O'Brien,Leonard C. Harrison +8 more
TL;DR: These findings identify proinflammatory CD11c+ ATMs as markers of insulin resistance in human obesity and indicates they metabolize lipid and may initiate adaptive immune responses.