Author
Benjamin J. Kaipers
Bio: Benjamin J. Kaipers is an academic researcher. The author has an hindex of 1, co-authored 1 publications receiving 1364 citations.
Papers
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TL;DR: This paper reviews formalisms that have been employed in mathematical biology and bioinformatics to describe genetic regulatory systems, in particular directed graphs, Bayesian networks, Boolean networks and their generalizations, ordinary and partial differential equations, qualitative differential equation, stochastic equations, and so on.
Abstract: The spatiotemporal expression of genes in an organism is determined by regulatory systems that involve a large number of genes connected through a complex network of interactions. As an intuitive understanding of the behavior of these systems is hard to obtain, computer tools for the modeling and simulation of genetic regulatory networks will be indispensable. This report reviews formalisms that have been employed in mathematical biology and bioinformatics to describe genetic regulatory systems, in particular directed graphs, Bayesian networks, ordinary and partial differential equations, stochastic equations, Boolean networks and their generalizations, qualitative differential equations, and rule-based formalisms. In addition, the report discusses how these formalisms have been used in the modeling and simulation of regulatory systems.
2,739 citations
TL;DR: A general approach to quali- tative modeling based on fuzzy logic is discussed, which proposes to use a fuzzy clustering method (fuzzy c-means method) to identify the structure of a fuzzy model.
Abstract: This paper discusses a general approach to quali- tative modeling based on fuzzy logic. The method of qualitative modeling is divided into two parts: fuzzy modeling and linguistic approximation. It proposes to use a fuzzy clustering method (fuzzy c-means method) to identify the structure of a fuzzy model. To clarify the advantages of the proposed method, it also shows some examples of modeling, among them a model of a dynamical process and a model of a human operator's control action.
2,447 citations
TL;DR: This three part series of papers is to provide a systematic and comparative study of various diagnostic methods from different perspectives and broadly classify fault diagnosis methods into three general categories and review them in three parts.
2,263 citations
TL;DR: This part of the paper reviews qualitative model representations and search strategies used in fault diagnostic systems and broadly classify them as topographic and symptomatic search techniques.
1,415 citations
01 Oct 2007
TL;DR: This book gathers chapters from some of the top international empirical software engineering researchers focusing on the practical knowledge necessary for conducting, reporting and using empirical methods in software engineering.
Abstract: This book gathers chapters from some of the top international empirical software engineering researchers focusing on the practical knowledge necessary for conducting, reporting and using empirical methods in software engineering. Topics and features include guidance on how to design, conduct and report empirical studies. The volume also provides information across a range of techniques, methods and qualitative and quantitative issues to help build a toolkit applicable to the diverse software development contexts
741 citations