Author
Benjamin R. Travis
Other affiliations: Affymetrix
Bio: Benjamin R. Travis is an academic researcher from Michigan State University. The author has contributed to research in topics: Osmium tetroxide & Catalysis. The author has an hindex of 12, co-authored 22 publications receiving 966 citations. Previous affiliations of Benjamin R. Travis include Affymetrix.
Topics: Osmium tetroxide, Catalysis, Ozonolysis, Osmium, Micelle
Papers
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TL;DR: A highly efficient, mild, and simple protocol is presented for the oxidation of aldehydes to carboxylic acids utilizing Oxone as the sole oxidant.
412 citations
TL;DR: A mild, organometallic alternative to ozonolysis utilizing oxone and OsO(4) is presented, which is a direct oxidation of olefins via the carbon-carbon cleavage of an osmate ester by the action of oxone.
Abstract: A mild, organometallic alternative to ozonolysis utilizing oxone and OsO4 is presented. This is a direct oxidation of olefins via the carbon−carbon cleavage of an osmate ester by the action of oxone. Twenty-four different olefins were converted to their corresponding ketones or carboxylic acids in high yields (>80%). Free alcohols, acetate- and benzyl-protected alcohols, and 1,2-diols were stable under these conditions. This method should be applicable for traditional organic synthesis.
249 citations
TL;DR: The chemistry of various salt forms of Oxone, an environmentally friendly oxidant, has been investigated in this article, showing that using purified reagents makes these reactions easier to workup and amenable to large scale synthesis because the amount of salt in the reaction has been greatly reduced.
64 citations
TL;DR: In this article, the OsO4-mediated oxidative cleavage of olefins is compatible with alternative, easier-to-handle osmium sources, and four different O4 sources were employed with favorable results.
53 citations
TL;DR: When added to classical detergent micelles CHOBIMALT was observed to dramatically enhance the thermal stability of solubilized hKOR1, and was found to be effective as a surfactant for membrane extraction.
Abstract: Cholesterol and its hemisuccinate and sulfate derivatives are widely used in studies of purified membrane proteins, but are difficult to solubilize in aqueous solution, even in the presence of detergent micelles. Other cholesterol derivatives do not form conventional micelles and lead to viscous solutions. To address these problems a cholesterol-based detergent, CHOBIMALT, has been synthesized and characterized. At concentrations above 3–4μM, CHOBIMALT forms micelles without the need for elevated temperatures or sonic disruption. Diffusion and fluorescence measurements indicated that CHOBIMALT micelles are large (210 ± 30 kDa). The ability to solubilize a functional membrane protein was explored using a G-protein coupled receptor, the human kappa opioid receptor type 1 (hKOR1). While CHOBIMALT alone was not found to be effective as a surfactant for membrane extraction, when added to classical detergent micelles CHOBIMALT was observed to dramatically enhance the thermal stability of solubilized hKOR1.
53 citations
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TL;DR: This paper presents results of aalysis experiment conducted at the Dalian Institute of Chemical Physics of Chinese Academy of Sciences (Dalian 116023) and Jingmen Technological College (Jingmen 448000) using gas chromatography for the recovery of Na6(CO3) from Na2SO4.
Abstract: Laboratory for Advanced Materials and New Catalysis, School of Chemistry and Materials Science, Hubei University, Wuhan 430062, China,Laboratory of Natural Gas Utilization and Applied Catalysis, Dalian Institute of Chemical Physics of Chinese Academy of Sciences, Dalian 116023,China, and Jingmen Technological College, Jingmen 448000, ChinaReceived June 30, 2004
864 citations
669 citations
TL;DR: The historical background and the efforts made to realize the catalytic utilization of hypervalent iodine reagents are highlighted, especially with focus on iodine(iii).
615 citations
TL;DR: It is shown that PMS without explicit activation undergoes direct reaction with a variety of compounds, including antibiotics, pharmaceuticals, phenolics, and commonly used singlet-oxygen traps and quenchers, specifically furfuryl alcohol (FFA), azide, and histidine.
Abstract: Peroxymonosulfate (HSO5– and PMS) is an optional bulk oxidant in advanced oxidation processes (AOPs) for treating wastewaters. Normally, PMS is activated by the input of energy or reducing agent to generate sulfate or hydroxyl radicals or both. This study shows that PMS without explicit activation undergoes direct reaction with a variety of compounds, including antibiotics, pharmaceuticals, phenolics, and commonly used singlet-oxygen (1O2) traps and quenchers, specifically furfuryl alcohol (FFA), azide, and histidine. Reaction time frames varied from minutes to a few hours at pH 9. With the use of a test compound with intermediate reactivity (FFA), electron paramagnetic resonance (EPR) and scavenging experiments ruled out sulfate and hydroxyl radicals. Although 1O2 was detected by EPR and is produced stoichiometrically through PMS self-decomposition, 1O2 plays only a minor role due to its efficient quenching by water, as confirmed by experiments manipulating the 1O2 formation rate (addition of H2O2) or li...
483 citations
TL;DR: The design of hypervalent iodine catalysts is focused on and the discovery and development of the oxidation of alcohols with the stoichiometric or catalytic use of hyperValent iodine compounds is reviewed.
420 citations