Author
Benny Drieghe
Bio: Benny Drieghe is an academic researcher from Ghent University Hospital. The author has contributed to research in topics: Blood pressure & Hemodynamics. The author has an hindex of 8, co-authored 27 publications receiving 316 citations.
Papers
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TL;DR: Generally accepted QRA and CDUS-derived indices of RAS severity overestimate the actual severity of R AS, which is likely the main cause of the disappointing results of renal angioplasty for renovascular hypertension.
Abstract: Aims A ratio of distal renal pressure to aortic pressure ( P d/ P a) <0.90 can be considered a threshold for defining a significant renal artery stenosis (RAS). The aim of this study was to compare renal angiography (QRA) and colour duplex ultrasound (CDUS) to pressure measurements in assessing RAS.
Methods and results In 56 RAS, percent diameter stenosis (DSangio), minimal luminal diameter (MLD), Doppler-derived peak systolic velocity (PSV), end-diastolic velocity (EDV), and renal-to-aortic ratio (RAR) were obtained and compared with the P d/ P a measured with a 0.014" pressure wire. P d/ P a correlated with angiography- and CDUS-derived parameters. The best correlation was observed with EDV ( R = −0.61). To identify stenosis associated with a P d/ P a 50%, MLD 180 cm/s, EDV > 90 cm/s and RAR > 3.5 were, respectively, 60%, 77%, 45%, 77% and 79%, yet, with a high proportion of false positives (38%, 15%, 55%, 11% and 15%, respectively) indicating an overestimation of the severity of the RAS by both QRA and CDUS. New cut-off values for QRA- and CDUS-derived indices were proposed.
Conclusion Generally accepted QRA and CDUS-derived indices of RAS severity overestimate the actual severity of RAS. This ‘overdiagnosis’ is likely the main cause of the disappointing results of renal angioplasty for renovascular hypertension.
104 citations
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TL;DR: Echocardiography remains a candidate first step in screening for PAH in an unselected systemic sclerosis population and the cost-effectiveness of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society guidelines is compared.
Abstract: Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. The DETECT screening algorithm is recommended in a high-risk SSc subgroup. This study aims to compare prospectively the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines, and to compare their cost-effectiveness in an unselected, day-to-day SSc population. Post hoc, screening according to the 2015 ESC/ERS guidelines using echocardiographic parameters alone ("2015 echo screening") or combined with the DETECT algorithm ("2015 combined screening") in high-risk subjects was analysed.195 consecutive SSc patients included in the Ghent University Hospital SSc cohort were screened using different algorithms.The referral rate for right heart catheterisation was 32% (63 out of 195 patients) (46/4/13/34/40 patients using the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). Right heart catheterisation was performed in 53 patients (84%) (36 (78%)/four (100%)/13 (100%)/28 (82%)/32 (80%) patients recommended by the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). PAH was diagnosed in three patients (incidence 1.5%·year-1, 95% CI 0.5-4.4), in whom all algorithms recommended a right heart catheterisation. The positive predictive value was 6% (95% CI 2-17%; three out of 49 patients) for the DETECT algorithm, 18% (95% CI 6-41%; three out of 17 patients) for the 2009 guidelines, 23% (95% CI 8-50%; three out of 13 patients) for both, 11% (95% CI 4-27%; three out of 28 patients) for the 2015 echo screening and 9% (95% CI 3-24%; three out of 32 patients) for the 2015 combined screening. The cost was EUR224/80/90/112 per patient using the DETECT algorithm/2009 guidelines/2015 echo screening/2015 combined screening.Echocardiography may remain a candidate first step for PAH screening in SSc.
44 citations
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TL;DR: The purpose of this study was to quantify the reduction in patient radiation dose during coronary angiography by a new X‐ray technology, and to assess its impact on diagnostic image quality.
Abstract: Objectives
The purpose of this study was to quantify the reduction in patient radiation dose during coronary angiography (CA) by a new X-ray technology, and to assess its impact on diagnostic image quality.
Background
Recently, a novel X-ray imaging technology has become available for interventional cardiology, using advanced image processing and an optimized acquisition chain for radiation dose reduction.
Methods
70 adult patients were randomly assigned to a reference X-ray system or the novel X-ray system. Patient demographics were registered and exposure parameters were recorded for each radiation event. Clinical image quality was assessed for both patient groups.
Results
With the same angiographic technique and a comparable patient population, the new imaging technology was associated with a 75% reduction in total kerma-area product (KAP) value (decrease from 47 Gycm2 to 12 Gycm2, P < 0.001). Clinical image quality showed an equivalent detail and contrast for both imaging systems. On the other hand, the subjective appreciation of noise was more apparent in images of the new image processing system, acquired at lower doses, compared to the reference system. However, the higher noise content did not affect the overall image quality score, which was adequate for diagnosis in both systems.
Conclusions
For the first time, we present a new X-ray imaging technology, combining advanced noise reduction algorithms and an optimized acquisition chain, which reduces patient radiation dose in CA drastically (75%), while maintaining diagnostic image quality. Use of this technology may further improve the radiation safety of cardiac angiography and interventions. © 2015 Wiley Periodicals, Inc.
39 citations
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TL;DR: In this paper, the authors performed office and 24-hour ambulatory BP recordings in 38 subjects who fulfilled the Holmes criteria for CFS and in 38 healthy control subjects (age 35.6 +/- 10.5 years), as well as short-term beat-to-beat BP and RR-interval recordings for 10 min in supine and standing position, and calculated spectral indices.
Abstract: 1. Chronic low blood pressure has been associated with fatigue and low mood. However, in the chronic fatigue syndrome (CFS) the blood pressure (BP) and heart rate profile and their variabilities have not been characterized as yet. 2. We performed office and 24 h ambulatory BP recordings in 38 subjects (age, 34.8 +/- 8.0 years) who fulfilled the Holmes criteria for CFS and in 38 healthy control subjects (age 35.6 +/- 10.5 years), as well as short-term beat-to-beat BP and RR-interval recordings for 10 min in supine and standing position, and calculated spectral indices. 3. In CFS office (123 +/- 19/70 +/- 12 mmHg) as well as 24-h, day- and night-time blood pressure values (116 +/- 11.1/71 +/- 11.1, 121 +/- 9.2/77 +/- 8.0 and 110 +/- 10.5/65 +/- 9.2 mmHg respectively) were within reference limits. 4. Heart rate was consistently higher (P < 0.01) in CFS patients, based on both office (77 +/- 12 compared with 68 +/- 12 beats min-1) and 24 h ambulatory recordings (77 +/- 12 compared with 67 +/- 15 beats min-1). 5. In supine position, spectral indices of BP variability (total, low-frequency and high-frequency variances) were all significantly (P < 0.01) lower in CFS. In standing position the differences disappeared. Analysis of RR-interval variability could not detect major alterations in autonomic function in CFS.
39 citations
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TL;DR: In this paper, the authors compared the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines, and to compare their cost-effectiveness in an unselected, day-to-day SSc population.
Abstract: Screening for pulmonary arterial hypertension (PAH) in systemic sclerosis (SSc) improves outcomes. The DETECT screening algorithm is recommended in a high-risk SSc subgroup. This study aims to compare prospectively the positive predictive value of screening using the DETECT algorithm and the 2009 European Society of Cardiology/European Respiratory Society (ESC/ERS) guidelines, and to compare their cost-effectiveness in an unselected, day-to-day SSc population. Post hoc, screening according to the 2015 ESC/ERS guidelines using echocardiographic parameters alone (“2015 echo screening”) or combined with the DETECT algorithm (“2015 combined screening”) in high-risk subjects was analysed. 195 consecutive SSc patients included in the Ghent University Hospital SSc cohort were screened using different algorithms. The referral rate for right heart catheterisation was 32% (63 out of 195 patients) (46/4/13/34/40 patients using the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). Right heart catheterisation was performed in 53 patients (84%) (36 (78%)/four (100%)/13 (100%)/28 (82%)/32 (80%) patients recommended by the DETECT algorithm/2009 guidelines/both/2015 echo screening/2015 combined screening). PAH was diagnosed in three patients (incidence 1.5%·year–1, 95% CI 0.5–4.4), in whom all algorithms recommended a right heart catheterisation. The positive predictive value was 6% (95% CI 2–17%; three out of 49 patients) for the DETECT algorithm, 18% (95% CI 6–41%; three out of 17 patients) for the 2009 guidelines, 23% (95% CI 8–50%; three out of 13 patients) for both, 11% (95% CI 4–27%; three out of 28 patients) for the 2015 echo screening and 9% (95% CI 3–24%; three out of 32 patients) for the 2015 combined screening. The cost was EUR224/80/90/112 per patient using the DETECT algorithm/2009 guidelines/2015 echo screening/2015 combined screening. Echocardiography may remain a candidate first step for PAH screening in SSc. Echocardiography remains a candidate first step in screening for PAH in an unselected systemic sclerosis population http://ow.ly/nuoh3096nRh
28 citations
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TL;DR: 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) as mentioned in this paper, covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries
Abstract: 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) : Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries
1,754 citations
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TL;DR: Endorsed by: the European Stroke Organisation (ESO) Authors/Task Force Members: Michal Tendera (Chairperson) (Poland), Victor Aboyans (Co-Chair person) (France), Marie-Louise Bartelink (The Netherlands), Iris Baumgartner (Switzerland).
Abstract: Endorsed by: the European Stroke Organisation (ESO) Authors/Task Force Members: Michal Tendera (Chairperson) (Poland), Victor Aboyans (Co-Chairperson) (France), Marie-Louise Bartelink (The Netherlands), Iris Baumgartner (Switzerland), Denis Cle ́ment (Belgium), Jean-Philippe Collet (France), Alberto Cremonesi (Italy), Marco De Carlo (Italy), Raimund Erbel (Germany), F. Gerry R. Fowkes (UK), Magda Heras (Spain), Serge Kownator (France), Erich Minar (Austria), Jan Ostergren (Sweden), Don Poldermans (The Netherlands), Vincent Riambau (Spain), Marco Roffi (Switzerland), Joachim Ro ̈ ther† (Germany), Horst Sievert (Germany), Marc van Sambeek (The Netherlands), Thomas Zeller (Germany).
1,335 citations
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TL;DR: In this article, the authors proposed a two-dimensional magnetic resonance imaging (2D) and three-dimensional (3D) image of the human femoral artery for the diagnosis of acute coronary syndrome.
Abstract: 2D
: two-dimensional
3D
: three-dimensional
ABI
: ankle–brachial index
ACAS
: Asymptomatic Carotid Atherosclerosis Study
ACCF
: American College of Cardiology Foundation
ACE
: angiotensin-converting enzyme
ACS
: acute coronary syndrome
ACST
: Asymptomatic Carotid Surgery Trial
ALI
: acute limb ischaemia
ASTRAL
: Angioplasty and Stenting for Renal Artery Lesions trial
BASIL
: Bypass versus Angioplasty in Severe Ischaemia of the Leg
BOA
: Dutch Bypass Oral Anticoagulants or Aspirin
CABG
: coronary artery bypass grafting
CAD
: coronary artery disease
CAPRIE
: Clopidogrel versus Aspirin in Patients at Risk for Ischaemic Events
CAPTURE
: Carotid ACCULINK/ACCUNET Post Approval Trial to Uncover Rare Events
CARP
: Coronary Artery Revascularization Prophylaxis
CAS
: carotid artery stenting
CASPAR
: Clopidogrel and Acetylsalicylic Acid in Bypass Surgery for Peripheral Arterial Disease
CASS
: Coronary Artery Surgery Study
CAVATAS
: CArotid and Vertebral Artery Transluminal Angioplasty Study
CEA
: carotid endarterectomy
CHARISMA
: Clopidogrel for High Atherothrombotic Risk and Ischaemic Stabilization, Management and Avoidance
CI
: confidence interval
CLEVER
: Claudication: Exercise Versus Endoluminal Revascularization
CLI
: critical limb ischaemia
CORAL
: Cardiovascular Outcomes in Renal Atherosclerotic Lesions
COURAGE
: Clinical Outcomes Utilization Revascularization and Aggressive Drug Evaluation
CPG
: Committee for Practice Guidelines
CREST
: Carotid Revascularization Endarterectomy vs. Stenting Trial
CT
: computed tomography
CTA
: computed tomography angiography
CVD
: cardiovascular disease
DECREASE-V
: Dutch Echocardiographic Cardiac Risk Evaluation
DRASTIC
: Dutch Renal Artery Stenosis Intervention Cooperative Study
DSA
: digital subtraction angiography
DUS
: duplex ultrasound/duplex ultrasonography
EACTS
: European Association for Cardio-Thoracic Surgery
EAS
: European Atherosclerosis Society
ECST
: European Carotid Surgery Trial
EPD
: embolic protection device
ESC
: European Society of Cardiology
ESH
: European Society of Hypertension
ESRD
: end-stage renal disease
EUROSCORE
: European System for Cardiac Operative Risk Evaluation
EVA-3S
: Endarterectomy Versus Angioplasty in Patients with Symptomatic Severe Carotid Stenosis
EXACT
: Emboshield and Xact Post Approval Carotid Stent Trial
GALA
: General Anaesthesia versus Local Anaesthesia for Carotid Surgery
GFR
: glomerular filtration rate
GRACE
: Global Registry of Acute Coronary Events
HbA1c
: glycated haemoglobin
HDL
: high-density lipoprotein
HOPE
: Heart Outcomes Prevention Evaluation
HR
: hazard ratio
IC
: intermittent claudication
ICSS
: International Carotid Stenting Study
IMT
: intima–media thickness
ITT
: intention to treat
LDL
: low-density lipoprotein
LEAD
: lower extremity artery disease
MACCEs
: major adverse cardiac and cerebrovascular events
MDCT
: multidetector computed tomography
MONICA
: Monitoring of Trends and Determinants in Cardiovascular Disease
MRA
: magnetic resonance angiography
MRI
: magnetic resonance imaging
NASCET
: North American Symptomatic Carotid Endarterectomy Trial
ONTARGET
: Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial
OR
: odds ratio
PAD
: peripheral artery diseases
PARTNERS
: Peripheral Arterial Disease Awareness, Risk, and Treatment: New Resources for Survival
PCI
: percutaneous coronary intervention
PET
: positron emission tomography
PRO-CAS
: Predictors of Death and Stroke in CAS
PTA
: percutaneous transluminal angioplasty
RAAS
: renin–angiotensin–aldosterone system
RADAR
: Randomized, Multicentre, Prospective Study Comparing Best Medical Treatment Versus Best Medical Treatment Plus Renal Artery Stenting in Patients With Haemodynamically Relevant Atherosclerotic Renal Artery Stenosis
RAS
: renal artery stenosis
RCT
: randomized controlled trial
REACH
: Reduction of Atherothrombosis for Continued Health
RR
: risk ratio
SAPPHIRE
: Stenting and Angioplasty with Protection in Patients at High Risk for Endarterectomy
SCAI
: Society for Cardiovascular Angiography and Interventions
SIR
: Society of Interventional Radiology
SPACE
: Stent-Protected Angioplasty versus Carotid Endarterectomy
SPARCL
: Stroke Prevention by Aggressive Reduction in Cholesterol Levels Study
STAR
: Stent Placement in Patients With Atherosclerotic Renal Artery Stenosis and Impaired Renal Function
SSYLVIA
: Stenting of Symptomatic Atherosclerotic Lesions in the Vertebral or Intracranial Arteries
SVMB
: Society for Vascular Medicine and Biology
TASC
: TransAtlantic Inter-Society Consensus
TIA
: transient ischaemic attack
UEAD
: upper extremity artery disease
VA
: vertebral artery
Guidelines summarize and evaluate all available evidence, at the time of the writing process, on a particular issue with the aim of assisting physicians in selecting the best management strategies for an individual patient, with a given condition, taking into account the impact on outcome, as well as the risk–benefit ratio of particular diagnostic or therapeutic means. Guidelines are no substitutes but are complements for textbooks and cover the ESC Core Curriculum topics. Guidelines and recommendations should help the physicians to make decisions in their daily practice. However, the final decisions concerning an individual patient must be made by the responsible physician(s).
A large number of Guidelines have been issued in recent years by the European Society of Cardiology (ESC) as well as by other societies and organizations. Because of the impact on clinical practice, quality criteria for the development of guidelines have been established in order to make all decisions transparent to the user. The recommendations for formulating and issuing ESC Guidelines can be found on the ESC website (http://www.escardio.org/guidelines-surveys/esc-guidelines/about/Pages/rules-writing.aspx). ESC Guidelines represent the official position of the ESC on a given topic and are regularly updated.
Members of this Task Force were selected by the ESC to represent professionals involved with the medical care of patients with this pathology. Selected experts in the field undertook a comprehensive review of the published evidence for diagnosis, management, and/or prevention of a given condition according to ESC Committee for Practice Guidelines (CPG) policy. A critical evaluation of diagnostic and therapeutic procedures was performed including assessment of the risk–benefit ratio. Estimates of expected health outcomes for larger populations were included, where data exist. The level of evidence and the strength of recommendation of particular treatment options were weighed and graded according to pre-defined scales, as outlined in Tables 1 and 2 . …
1,266 citations
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TL;DR: Multivariate statistical analyses suggest that gastrointestinal disorders, psychiatric disorders, and nongastrointestinal somatic disorders are distinct disorders and not manifestations of a common somatization disorder, but their strong comorbidity suggests a common feature important to their expression, which is most likely psychological.
1,048 citations
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Fukuoka University1, Kindai University2, Teikyo University3, Nagoya Gakuin University4, International University of Health and Welfare5, Jichi Medical University6, Dokkyo Medical University7, Mie University8, Tohoku University9, Kurume University10, Osaka University11, Tokyo Medical University12, Kawasaki Medical School13, Saitama Medical University14, University of Miyazaki15, Kyushu University16, Ehime University17, National Defense Medical College18, Shiga University of Medical Science19, Kumamoto University20, Kansai University of Welfare Sciences21, University of the Ryukyus22, Sapporo Medical University23, Oita University24, Yokohama City University25, Yokohama City University Medical Center26
TL;DR: The story of the life and times of Toshihiko Umemura and his family in the years leading up to and including his death.
Abstract: Satoshi Umemura ● Hisatomi Arima ● Shuji Arima ● Kei Asayama ● Yasuaki Dohi ● Yoshitaka Hirooka ● Takeshi Horio ● Satoshi Hoshide ● Shunya Ikeda ● Toshihiko Ishimitsu ● Masaaki Ito ● Sadayoshi Ito ● Yoshio Iwashima ● Hisashi Kai ● Kei Kamide ● Yoshihiko Kanno ● Naoki Kashihara ● Yuhei Kawano ● Toru Kikuchi ● Kazuo Kitamura ● Takanari Kitazono ● Katsuhiko Kohara ● Masataka Kudo ● Hiroo Kumagai ● Kiyoshi Matsumura ● Hideo Matsuura ● Katsuyuki Miura ● Masashi Mukoyama ● Satoko Nakamura ● Takayoshi Ohkubo ● Yusuke Ohya ● Takafumi Okura ● Hiromi Rakugi ● Shigeyuki Saitoh ● Hirotaka Shibata ● Tatsuo Shimosawa ● Hiromichi Suzuki ● Shori Takahashi ● Kouichi Tamura ● Hirofumi Tomiyama ● Takuya Tsuchihashi ● Shinichiro Ueda ● Yoshinari Uehara ● Hidenori Urata ● Nobuhito Hirawa
903 citations