Benoit Bilanges

TL;DR: A better understanding of how the different PI3K isoforms are regulated and control signalling could uncover their roles in pathology and reveal in which disease contexts their blockade could be most beneficial.

TL;DR: It is found that chronic p110α partial inactivation in mice protects from age‐related reduction in insulin sensitivity, glucose tolerance and fat accumulation, and extends the lifespan of male mice, indicating that prolonged PI3K inhibition, as intended in human cancer treatment, might not negatively impact on organismal metabolism.

TL;DR: Exposure of cells to ambient conditions affects the activity of signaling networks previously implicated in metabolic and growth factor signaling, and it is observed that maintaining cells in ice modified but did not completely abolish this metabolic stress response.

TL;DR: It is concluded that PI3K‐III is essential for endosome fission/recycling; and besides its role in endocytic entry, dynamin also supports tubulation of recycling endosomes.

TL;DR: In this article, the authors proposed a personalized protein kinase inhibitor for cancer therapy, which has shown great promise in cancer therapy and has been shown to be effective against multiple target protein kinases.