B
Benoît Malpaux
Researcher at François Rabelais University
Publications - 140
Citations - 6249
Benoît Malpaux is an academic researcher from François Rabelais University. The author has contributed to research in topics: Melatonin & Luteinizing hormone. The author has an hindex of 45, co-authored 140 publications receiving 5883 citations. Previous affiliations of Benoît Malpaux include Institut national de la recherche agronomique & Centre national de la recherche scientifique.
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Journal ArticleDOI
Biology of mammalian photoperiodism and the critical role of the pineal gland and melatonin.
TL;DR: Indoleamine at the level of the central nervous system is a modulation of GnRH secretion but it does not act directly on GnRH neurones; rather, its action involves a complex neural circuit of interneurones that includes at least dopaminergic, serotoninergic and aminoacidergic neurones.
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New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Valérie Audinot,François Mailliet,Chantal Lahaye-Brasseur,Anne Bonnaud,Aude Le Gall,Christophe Amossé,Sandra Dromaint,Marianne Rodriguez,Nadine Nagel,Jean-Pierre Galizzi,Benoît Malpaux,Gérald Guillaumet,Daniel Lesieur,François Lefoulon,Pierre Renard,Philippe Delagrange,Jean A. Boutin +16 more
TL;DR: The most potent melatonin receptor agonist, S 25150, is discovered, so far reported in the literature, and new types of selective antagonists, such as S 25567 and S 26131 for MT1 and S 24601 for MT2 are reported.
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Control of sheep and goat reproduction: Use of light and melatonin
Philippe Chemineau,Benoît Malpaux,J. A Delgadillo,Y. Guérin,J.P. Ravault,J. Thimonier,J. Pelletier +6 more
TL;DR: Knowledge of the different effects of photoperiod on neuroendocrine pathways and the reproductive activity in sheep and goats has allowed us to successfully apply light treatments to control seasonal reproductiveactivity in field conditions and in males raised in AI centres.
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High Melatonin Concentrations in Third Ventricular Cerebrospinal Fluid Are Not due to Galen Vein Blood Recirculating through the Choroid Plexus
Donal C. Skinner,Benoît Malpaux +1 more
TL;DR: The discovery of periventricular sites of action adjacent to the third ventricle forced the investigation of the dynamics of cerebrospinal fluid melatonin release and the source of this melatonin to investigate the bioavailability of melatonin in the brain.
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Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205
Surajit Ganguly,Joan L. Weller,Anthony D. Ho,Philippe Chemineau,Benoît Malpaux,David C. Klein +5 more
TL;DR: Findings indicate that ovine AANAT is dual-phosphorylated, and light exposure at night decreases T31 and S205 phosphorylation, consistent with a regulatory role of both sites.