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Bernard P. Roques
Researcher at French Institute of Health and Medical Research
Publications - 500
Citations - 24838
Bernard P. Roques is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Enkephalin & Receptor. The author has an hindex of 74, co-authored 499 publications receiving 24213 citations. Previous affiliations of Bernard P. Roques include Paris Descartes University & Rhône-Poulenc.
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Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the mu-opioid-receptor gene.
Hans W. D. Matthes,Rafael Maldonado,Frédéric Simonin,Olga Valverde,Susan Slowe,Ian Kitchen,Katia Befort,Andrée Dierich,Marianne Le Meur,Pascal Dollé,Eleni T. Tzavara,Jacques Hanoune,Bernard P. Roques,Brigitte L. Kieffer +13 more
TL;DR: Investigation of the behavioural effects of morphine reveals that a lack of μ receptors abolishes the analgesic effect of morphine, as well as place-preference activity and physical dependence, and concludes that the µ-opioid-receptor gene product is a mandatory component of the opioid system for morphine action.
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Unresponsiveness to Cannabinoids and Reduced Addictive Effects of Opiates in CB1 Receptor Knockout Mice
Catherine Ledent,Olga Valverde,G Cossu,François Petitet,Jean-François Aubert,Françoise Beslot,Georg Andrees Bohme,Assunta Imperato,Thierry Pedrazzini,Bernard P. Roques,Gilbert Vassart,Walter Fratta,Marc Parmentier +12 more
TL;DR: Observations suggest that the CB1 receptor is involved in the motivational properties of opiates and in the development of physical dependence and extend the concept of an interconnected role of CB1 and opiate receptors in the brain areas mediating addictive behavior.
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The enkephalinase inhibitor thiorphan shows antinociceptive activity in mice
Bernard P. Roques,Marie-Claude Fournie-Zaluski,E. Soroca,J.M. Lecomte,Bernard Malfroy,C. Llorens,J C Schwartz +6 more
TL;DR: Thiorphan is reported here that this compound, thiorphan [(DL-3-mercapto-2-benzylpropanoyl)-glycine; patent no. 8008601] protects the enkephalins from the action of enkephalinase in vitro in nanomolar concentration and in vivo after either intracerebroventricular or systemic administration.
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High-affinity enkephalin-degrading peptidase in brain is increased after morphine
TL;DR: The presence of a high-affinity peptidase in a particulate fraction of mouse striatum splitting the Leu-enkephalin molecule with release of a tripeptide fragment and exhibiting definite substrate specificity suggests that it might be associated with enkphalinergic transmission.
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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Rafael Maldonado,Adolfo Saiardi,Olga Valverde,Tarek A. Samad,Bernard P. Roques,Emiliana Borrelli +5 more
TL;DR: The D2 receptor plays a crucial role in the motivational component of drug addiction, as mice lacking D2 receptors behaved the same as wild-type mice when food is used as reward.