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Bernd Meibohm
Researcher at University of Tennessee Health Science Center
Publications - 189
Citations - 9431
Bernd Meibohm is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Pharmacokinetics & Population. The author has an hindex of 47, co-authored 172 publications receiving 8250 citations. Previous affiliations of Bernd Meibohm include University of South Carolina & National Institutes of Health.
Papers
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Journal ArticleDOI
Pharmacokinetics of Monoclonal Antibodies
Josiah T. Ryman,Bernd Meibohm +1 more
TL;DR: This tutorial will review major drug disposition processes relevant for mAbs, and will highlight product‐specific and patient‐specific factors that modulate their pharmacokinetic (PK) behavior and need to be considered for successful clinical therapy.
Journal ArticleDOI
How Important Are Gender Differences in Pharmacokinetics
TL;DR: Gender-related differences in pharmacokinetics have frequently been considered as potentially important determinants for the clinical effectiveness of drug therapy and intensive future research efforts are needed to assess the full scope and impact of pharmacodynamic gender disparity on applied pharmacotherapy.
Journal ArticleDOI
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
María Soler Artigas,Daan W. Loth,Louise V. Wain,Sina A. Gharib,Ma'en Obeidat,Wenbo Tang,Guangju Zhai,Guangju Zhai,Jing Hua Zhao,Albert V. Smith,Jennifer E. Huffman,Eva Albrecht,C.M. Jackson,David M. Evans,Gemma Cadby,Gemma Cadby,Myriam Fornage,Ani Manichaikul,Lorna M. Lopez,Toby Johnson,Melinda C. Aldrich,Thor Aspelund,Ins Barroso,Ins Barroso,Harry Campbell,Patricia A. Cassano,David Couper,Gudny Eiriksdottir,Nora Franceschini,Melissa E. Garcia,Christian Gieger,Gauti Kjartan Gislason,Ivica Grković,Christopher J Hammond,Dana B. Hancock,Dana B. Hancock,Tamara B. Harris,Adaikalavan Ramasamy,Adaikalavan Ramasamy,Susan R. Heckbert,Susan R. Heckbert,Markku Heliövaara,Georg Homuth,Pirro G. Hysi,Alan James,Alan James,Stipan Janković,Bonnie R. Joubert,Stefan Karrasch,Norman Klopp,Beate Koch,Stephen B. Kritchevsky,Lenore J. Launer,Yongmei Liu,Laura R. Loehr,Kurt Lohman,Ruth J. F. Loos,Thomas Lumley,Khalid A. Al Balushi,Wei Ang,R. Graham Barr,John Beilby,John D Blakey,Mladen Boban,Vesna Boraska,Jonas Brisman,John Britton,Guy Brusselle,Cyrus Cooper,Ivan Curjuric,Santosh Dahgam,Ian J. Deary,Shah Ebrahim,Mark Eijgelsheim,Clyde Francks,Darya Gaysina,Raquel Granell,Xiangjun Gu,John L. Hankinson,Rebecca Hardy,Sarah E. Harris,John Henderson,Amanda P. Henry,Aroon D. Hingorani,Albert Hofman,Patrick G. Holt,Jennie Hui,Jennie Hui,Michael Hunter,Michael Hunter,Medea Imboden,Karen A. Jameson,Shona M. Kerr,Ivana Kolcic,Florian Kronenberg,Jason Z. Liu,Jonathan Marchini,Tricia M. McKeever,Andrew D. Morris,Anna-Carin Olin,David J. Porteous,Dirkje S. Postma,Stephen S. Rich,Susan M. Ring,Fernando Rivadeneira,Thierry Rochat,Avan Aihie Sayer,Ian Sayers,Peter D. Sly,George Davey Smith,Akshay Sood,John M. Starr,André G. Uitterlinden,Judith M. Vonk,S. Goya Wannamethee,Peter H. Whincup,Cisca Wijmenga,O. Dale Williams,Andrew Wong,Massimo Mangino,Kristin D. Marciante,Wendy L. McArdle,Bernd Meibohm,Alanna C. Morrison,Kari E. North,Ernst Omenaas,Lyle J. Palmer,Lyle J. Palmer,Kirsi H. Pietiläinen,Isabelle Pin,Ozren Polasek,Anneli Pouta,Bruce M. Psaty,Bruce M. Psaty,Anna-Liisa Hartikainen,Taina Rantanen,Samuli Ripatti,Samuli Ripatti,Jerome I. Rotter,Igor Rudan,Igor Rudan,Alicja R. Rudnicka,Holger Schulz,So-Youn Shin,Tim D. Spector,Ida Surakka,Ida Surakka,Veronique Vitart,Henry Völzke,Nicholas J. Wareham,Nicole M. Warrington,Nicole M. Warrington,H.-Erich Wichmann,Sarah H. Wild,Jemma B. Wilk,Matthias Wjst,Alan F. Wright,Lina Zgaga,Lina Zgaga,Tatijana Zemunik,Craig E. Pennell,Fredrik Nyberg,Fredrik Nyberg,Diana Kuh,John W. Holloway,H. Marike Boezen,Debbie A Lawlor,Richard W Morris,Nicole Probst-Hensch,Jaakko Kaprio,Jaakko Kaprio,James F. Wilson,Caroline Hayward,Mika Kähönen,Joachim Heinrich,Arthur W. Musk,Arthur W. Musk,Deborah Jarvis,Deborah Jarvis,Sven Gläser,Sven Gläser,Marjo-Riitta Järvelin,Bruno H. Ch. Stricker,Bruno H. Ch. Stricker,Paul Elliott,Paul Elliott,George T. O'Connor,George T. O'Connor,David P. Strachan,Stephanie J. London,Ian P. Hall,Vilmundur Gudnason,Martin D. Tobin +192 more
TL;DR: This article identified new regions showing association with pulmonary function in or near MFAP2, TGFB2, HDAC4, RARB, MECOM (also known as EVI1), SPATA9, ARMC2, NCR3, ZKSCAN3, CDC123, C10orf11, LRP1, CCDC38, MMP15, CFDP1 and KCNE2.
Journal ArticleDOI
Population pharmacokinetics of therapeutic monoclonal antibodies.
Nathanael L. Dirks,Bernd Meibohm +1 more
TL;DR: Many features of the population pharmacokinetics of currently used therapeutic mAbs are similar, despite differences in their pharmacological targets and studied patient populations.
Journal ArticleDOI
Modeling of pharmacokinetic/pharmacodynamic (PK/PD) relationships: concepts and perspectives.
Hartmut Derendorf,Bernd Meibohm +1 more
TL;DR: Pharmacokinetic/pharmacodynamic (PK/PD)-modeling links dose-concentration relationships (PK) and concentration-effect relationships (PD), thereby facilitating the description and prediction of the time course of drug effects resulting from a certain dosing regimen as discussed by the authors.