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Besim Ogretmen

Researcher at Medical University of South Carolina

Publications -  154
Citations -  17215

Besim Ogretmen is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Ceramide & Sphingolipid. The author has an hindex of 53, co-authored 140 publications receiving 14501 citations. Previous affiliations of Besim Ogretmen include Illinois Institute of Technology & Sewanee: The University of the South.

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Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, +2522 more
- 21 Jan 2016 - 
TL;DR: In this paper, the authors present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macro-autophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes.
Journal ArticleDOI

Biologically active sphingolipids in cancer pathogenesis and treatment.

Besim Ogretmen, +1 more
- 01 Aug 2004 - 
TL;DR: This work has shown that ceramide — a central molecule in sphingolipid metabolism — in effect functions as a tumour-suppressor lipid, inducing antiproliferative and apoptotic responses in various cancer cells, and that S1P induces responses that, on aggregate, render S 1P a tumours-promoting lipid.
Journal ArticleDOI

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)

Daniel J. Klionsky, +2983 more
- 08 Feb 2021 - 
TL;DR: In this article, the authors present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes.
Journal ArticleDOI

Sphingolipid metabolism in cancer signalling and therapy

Besim Ogretmen
- 01 Jan 2018 - 
TL;DR: How ceramide-induced cellular stress mediates cancer cell death through various mechanisms involving the induction of apoptosis, necroptosis and/or mitophagy is summarized.
Journal ArticleDOI

Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy

R. David Sentelle, +11 more
- 01 Oct 2012 - 
TL;DR: A novel receptor function of ceramide for anchoring LC3B-II-autophagolysosomes to mitochondrial membranes is suggested, defining a key mechanism for the induction of lethal mitophagy.