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Bhaskar Mohan Murari

Bio: Bhaskar Mohan Murari is an academic researcher from VIT University. The author has contributed to research in topics: Blood Glucose Measurement & Pyranine. The author has an hindex of 8, co-authored 24 publications receiving 392 citations. Previous affiliations of Bhaskar Mohan Murari include Indian Institutes of Technology & Indian Institute of Technology Delhi.

Papers
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Journal ArticleDOI
TL;DR: Various methods of glucose monitoring are reviewed and overall emphasis is laid on the development of NIRS (near-infrared spectroscopy) based non-invasive glucose monitoring.

251 citations

Proceedings ArticleDOI
24 Mar 2014
TL;DR: The present work is focused on development of non-invasive blood glucose measurement sensor system using Near-infrared (NIR) technique and results are promising and show the potential of using NIR for glucose measurement.
Abstract: Diabetes is a metabolic pathological condition of concern, which affects vital organs of body if not diagnosed and treated on time. Regular monitoring of blood glucose is important to avoid complication of diabetes. Commonly used glucose measurement methods are invasive which generally involves finger puncturing. These methods are painful and frequent pricking cause calluses on the skin and have risk of spreading infectious diseases. Therefore there is need to develop a non-invasive monitoring system which can measure blood glucose continuously without much problem. The present work is focused on development of non-invasive blood glucose measurement sensor system using Near-infrared (NIR) technique. Initially in-vitro glucose measurement prototype is developed using continuous wave (CW) from NIR LED (940 nm) to check the sensitivity of the system for different glucose concentrations. Later a Sensor patch was designed using LED and a photodiode to observe diffused reflectance spectra of blood from the human forearm. Diffused reflectance spectra of the subjects obtained with this technique was also compared with commercially available invasive finger tip gluco-meter. The results are promising and show the potential of using NIR for glucose measurement.

88 citations

Journal ArticleDOI
TL;DR: The results indicated that hydrophobic interactions were the predominant intermolecular forces in stabilizing BSA-Hoechst 33258 complex and the possible implications of these results will be on designing better therapeutic minor groove binding drug molecules.
Abstract: Hoechst 33258 belongs to bisbenzimidazole class of molecules having anticancer properties for their ability to inhibit topoisomerase and many other cellular processes. The aim of the present study is to understand the nature of Hoechst 33258-bovine serum albumin (BSA) binding interactions by using absorption, fluorescence and circular dichrorism (CD) measurements under simulative physiological conditions. The absorption spectra of BSA indicated the binding of Hoechst 33258 with BSA. The analysis of fluorescence data indicated the presence of both dynamic and static quenching mechanism in the binding. The associative binding constant and number of binding sites were found to be K=2.08=107 M−1 and n=1.36 respectively. Biexponential fluorescence lifetime distribution of Hoechst 33258 in the presence of BSA has altered viz. τ1 was increased significantly from 0.3 ns (60%) to 1.2 ns (13%) whereas a marginal increase in τ2 from 3.6 ns (40%) to 4.0 ns (87%). Fluorescence anisotropy value of Hoechst 33258 has increased from 0.14 to 0.34 upon the addition of BSA. Thermodynamic parameters were also calculated using Van't Hoff plot by conducting fluorescence titration at four different temperatures, ΔH=+102.785 kJ mol−1, ΔS=+490.18 kJ mol−1, ΔG=−491.708 kJ mol−1. The CD spectrum of BSA revealed that the binding of Hoechst 33258 to BSA causes loss in the secondary structure but increases the thermal stability of the protein. The results indicated that hydrophobic interactions were the predominant intermolecular forces in stabilizing BSA-Hoechst 33258 complex. The possible implications of these results will be on designing better therapeutic minor groove binding drug molecules.

43 citations

Journal ArticleDOI
TL;DR: Two label-free fluorescent aptasensor methods for the detection of S. typhimurium through the Förster resonance energy transfer between Rhodamine B and gold nanoparticles and some insights into the molecular interactions between the aptamer and the bacterial target are provided.

33 citations

Journal ArticleDOI
TL;DR: In this article, the authors reported fluorescence emission and excited state lifetime measurements on fluorescent probes entrapped in TEOS sol-gel for monitoring the physico-chemical processes for characterization and monitoring of local environment (pores) of dopant molecule (fluorescent probes) for construction of sensing layer for optical transducer.

23 citations


Cited by
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01 Jan 2016
TL;DR: The principles of fluorescence spectroscopy is universally compatible with any devices to read and is available in the digital library an online access to it is set as public so you can download it instantly.
Abstract: Thank you very much for downloading principles of fluorescence spectroscopy. As you may know, people have look hundreds times for their favorite novels like this principles of fluorescence spectroscopy, but end up in malicious downloads. Rather than reading a good book with a cup of tea in the afternoon, instead they cope with some harmful bugs inside their desktop computer. principles of fluorescence spectroscopy is available in our digital library an online access to it is set as public so you can download it instantly. Our digital library spans in multiple locations, allowing you to get the most less latency time to download any of our books like this one. Kindly say, the principles of fluorescence spectroscopy is universally compatible with any devices to read.

2,960 citations

Journal ArticleDOI
12 Aug 2017-Sensors
TL;DR: This review highlights recent advances towards non-invasive and continuous glucose monitoring devices, with a particular focus placed on monitoring glucose concentrations in alternative physiological fluids to blood.
Abstract: This review highlights recent advances towards non-invasive and continuous glucose monitoring devices, with a particular focus placed on monitoring glucose concentrations in alternative physiological fluids to blood.

520 citations

01 Jan 1965

319 citations

Journal ArticleDOI
TL;DR: The answer to the question in the title is an unequivocal "yes" but maybe not necessarily in the areas where most of the published research is focused.
Abstract: As diabetes is considered one of the biggest health care challenges of the coming decades substantial effort is being made to develop novel glucose monitoring systems, this includes thousands of articles which are being published every year. To the question in the title, we answer an unequivocal "yes" but maybe not necessarily in the areas where most of the published research is focused.

179 citations

Journal ArticleDOI
04 Dec 2020-Sensors
TL;DR: The research progress and major challenges of non-invasive blood glucose detection technology in recent years are reviewed, and it is divided into three categories: optics, microwave and electrochemistry, based on the detection principle.
Abstract: In recent years, with the rise of global diabetes, a growing number of subjects are suffering from pain and infections caused by the invasive nature of mainstream commercial glucose meters. Non-invasive blood glucose monitoring technology has become an international research topic and a new method which could bring relief to a vast number of patients. This paper reviews the research progress and major challenges of non-invasive blood glucose detection technology in recent years, and divides it into three categories: optics, microwave and electrochemistry, based on the detection principle. The technology covers medical, materials, optics, electromagnetic wave, chemistry, biology, computational science and other related fields. The advantages and limitations of non-invasive and invasive technologies as well as electrochemistry and optics in non-invasives are compared horizontally in this paper. In addition, the current research achievements and limitations of non-invasive electrochemical glucose sensing systems in continuous monitoring, point-of-care and clinical settings are highlighted, so as to discuss the development tendency in future research. With the rapid development of wearable technology and transdermal biosensors, non-invasive blood glucose monitoring will become more efficient, affordable, robust, and more competitive on the market.

157 citations