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Bhupinder Pal
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 55
Citations - 5014
Bhupinder Pal is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 21, co-authored 46 publications receiving 4089 citations. Previous affiliations of Bhupinder Pal include University of Melbourne & La Trobe University.
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Journal ArticleDOI
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers
Elgene Lim,Elgene Lim,François Vaillant,Di Wu,Di Wu,Natasha C. Forrest,Bhupinder Pal,Adam H. Hart,Marie Liesse Asselin-Labat,David E. Gyorki,David E. Gyorki,Teresa Ward,Audrey Partanen,Frank Feleppa,Lily I. Huschtscha,Heather Thorne,Stephen B. Fox,Max Yan,Juliet D. French,Melissa A. Brown,Gordon K. Smyth,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +24 more
TL;DR: It is found that breast tissue from BRCA1 mutation carriers harbors an expanded luminal progenitor population that shows factor-independent growth in vitro, and the findings suggest that an aberrant luminalprogenitor population is a target for transformation in BRCa1-associated basal tumors.
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Control of mammary stem cell function by steroid hormone signalling
Marie Liesse Asselin-Labat,François Vaillant,Julie Sheridan,Bhupinder Pal,Di Wu,Di Wu,Evan R. Simpson,Hisataka Yasuda,Gordon K. Smyth,Gordon K. Smyth,T. John Martin,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader,Jane E. Visvader +15 more
TL;DR: It is demonstrated that mouse mammary stem cells (MaSCs) are highly responsive to steroid hormone signalling, despite lacking the oestrogen and progesterone receptors, and indicates that breast cancer chemoprevention may be achieved, in part, through suppression of MaSC function.
Journal ArticleDOI
Notch signaling regulates mammary stem cell function and luminal cell-fate commitment.
Toula Bouras,Bhupinder Pal,François Vaillant,Gwyndolen Harburg,Marie Liesse Asselin-Labat,Samantha R. Oakes,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Jane E. Visvader +8 more
TL;DR: It is shown that knockdown of the canonical Notch effector Cbf-1 in the MaSC-enriched population results in increased stem cell activity in vivo as well as the formation of aberrant end buds, implying a role for endogenous Notch signaling in restricting MaSC expansion.
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Transcriptome analyses of mouse and human mammary cell subpopulations reveal multiple conserved genes and pathways
Elgene Lim,Elgene Lim,Di Wu,Di Wu,Bhupinder Pal,Toula Bouras,Marie Liesse Asselin-Labat,François Vaillant,Hideo Yagita,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Gordon K. Smyth,Gordon K. Smyth,Jane E. Visvader,Jane E. Visvader +15 more
TL;DR: The conservation of genes and pathways across species further validates the use of the mouse as a model to study mammary gland development and highlights pathways that are likely to govern cell-fate decisions and differentiation.
Journal ArticleDOI
Targeting BCL-2 with the BH3 Mimetic ABT-199 in Estrogen Receptor-Positive Breast Cancer
François Vaillant,Delphine Merino,Delphine Merino,Lily Lee,Lily Lee,Kelsey Breslin,Bhupinder Pal,Bhupinder Pal,Matthew E. Ritchie,Matthew E. Ritchie,Gordon K. Smyth,Gordon K. Smyth,Michael Christie,Michael Christie,Michael Christie,Louisa J. Phillipson,Louisa J. Phillipson,Christopher J. Burns,Christopher J. Burns,G. Bruce Mann,G. Bruce Mann,Jane E. Visvader,Jane E. Visvader,Geoffrey J. Lindeman,Geoffrey J. Lindeman,Geoffrey J. Lindeman +25 more
TL;DR: Unexpectedly, BH3 mimetics were found to counteract the side effect of tamoxifen-induced endometrial hyperplasia and synergized with phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitors in eliciting apoptosis.