Bianca B. M. Garcia

TL;DR: Structural analyses show that that chitosomes-pDNA complexes appear to have multilamellar vesicle structures hosting pDNA in-between bilayers which favor interaction with cell membrane and delivery of pDNA.

TL;DR: It is demonstrated that peptiplexes deliver double-stranded 200 bp DNA into HeLa cells, indicating its potential for preparing non-viral vectors for oligonucleotides through noncovalent strategies and highlighting the role of uncharged amino acids for structuration, and thus for the ability of Penetratin to cross cell membranes.

TL;DR: A comprehensive study on the nanoscale structure of noncovalent complexes formed between Penetratin and DNA and it is shown for the first time that condensation is accompanied by random-to--sheet transitions of peptide secondary structure, demonstrating that nucleic acids behave as a structuring agent upon complexation.

TL;DR: Results show that SF ternary hybrid microgels facilitated the entrapment of hydrophobic nanocarriers with encapsulation efficiency (EE) from 83 to 98% keeping a better sustainable profile release than nonhybrid ALGmicrogels, being a good strategy to be used as an efficient platform in using macro and nanoencapsulated systems for drug delivery.

TL;DR: The self-assembling properties of PFVYLI are examined and its ability to form noncovalent complexes with nucleic acids that retain β-sheet pairing found in amyloid aggregates is investigated, suggesting that the propensity to formAmyloidogenic aggregates may trigger endosomal entrapment.