Bibiana Sans-Sansa

TL;DR: Patients with schizophrenia show both failure to activate and failure to deactivate during performance of a working memory task, including an area in the anterior prefrontal/anterior cingulate cortex that corresponds to one of the two midline components of the ‘default mode network’ implicated in functions related to maintaining one's sense of self.

TL;DR: Both prefrontal cortical and default mode network dysfunction appear to characterise bipolar depression, and the former, but not the latter, is associated with symptom severity.

TL;DR: The findings point to a relationship between FTD in schizophrenia and structural brain pathology in brain areas involved in language and executive function.

TL;DR: It is suggested that, in addition to reduced prefrontal activation, failure of de-activation is an important functional imaging abnormality in mania, and its location in the medial prefrontal cortex implies default mode network dysfunction in the disorder.