Bidyut Basak

Bio: Bidyut Basak is an academic researcher from University of Calcutta. The author has contributed to research in topics: Reagent & Nardostachys jatamansi. The author has an hindex of 9, co-authored 25 publications receiving 353 citations.

Original research article The reversible antifertility effect of Piper betle Linn. on Swiss albino male mice

Abstract: To study the antifertility effect of an extract (alcoholic) of the leaf-stalk of Piper betle Linn., one set of experiments with two different doses in Swiss male albino mice were evaluated. Initially, 500 mg of the leaf-stalk extractive for 30 days and then 1000 mg for next 30 days/animal/day/kg body weight were administered orally. The extract reduced fertility to 0% within 60 days. Suppression of cauda epididymal sperm count and motility (p ,0.05) was observed. Biochemical parameters did not show any marked alterations in testosterone content in serum nor 17b-hydroxysteroid dehydrogenase (17b-HSD) activity in testes although fructose content in seminal vesicles was reduced as are the weights of reproductive organs. The cholesterol content in testes increased, although not appreciably. After cessation of drug (plant extract) treatment, the altered parameters recovered. Results suggest that the contraceptive effect of the extract of leaf-stalk of Piper betle Linn. is mainly on the maturation process of spermatozoa in epididymides without influencing hystemic hormonal profiles. Withdrawal of the extract restored all altered parameters including organ weights and fertility after 60 days. © 2001 Elsevier Science Inc. All rights reserved.

Structure and stereochemistry of nardostachysin, a new terpenoid ester constituent of the rhizomes of Nardostachys jatamansi.

Abstract: The structure and stereochemistry of a new terpenoid ester, nardostachysin (1), isolated from the rhizomes of Nardostachys jatamansi, were established as the 7‘,8‘-dihydroxy-4‘-methylene hexahydrocyclopenta[c]pyran-1‘-one-8‘-methyl ester of 7,9-guaiadien-14-oic acid, by spectral and chemical studies.

Modified ninhydrin spray reagent for the identification of amino acids on thin-layer chromatography plates

Abstract: Identification of amino acids is essential for the evaluation of protein structure and also for the determination of the presence of amino acids in natural products. D-Camphor-10-sulphonic acid–ninhydrin can produce various distinguishable colours when it reacts with amino acids, whereas ninhydrin itself produces the same purple colour with most of them. The detection limits for amino acids for the proposed spray reagent range between 0.4 and 2.0 µg, under cold conditions, and 0.2 and 1.0 µg, after heating.

Indium-catalyzed annulation of 2-aryl- and 2-heteroarylindoles with propargyl ethers: concise synthesis and photophysical properties of diverse aryl- and heteroaryl-annulated[a]carbazoles.

Abstract: Treatment of 2-aryl- and 2-heteroarylindoles with propargyl ethers in the presence of a catalytic amount of indium nonafluorobutanesulfonate [In(ONf)3] gave aryl- and heteroaryl-annulated[a]carbazoles in good yields. The synthetically attractive feature is reflected by its applicability to a wide range of 2-aryl- and 2-heteroarylindoles. In the annulation reaction, propargyl ethers act as C3 sources (HC≡C−CH2OR). Among these, two carbon atoms are incorporated into the product as members of a newly constructed aromatic ring and the remaining carbon atom forms a methyl group on the aromatic ring, where the methyl group is always located next to the C3 position of the indole nucleus. The methyl group can be easily removed through SeO2 oxidation followed by decarbonylation with RhCl(CO)(PPh3)2−Ph2P(CH2)3PPh2 as a catalyst. The new annulation strategy is applicable also to symmetrical dimers such as bithiophene and bifuran derivatives. Mechanistic studies suggest that the first step is addition reaction initia...