B
Biju Issac
Researcher at University of Miami
Publications - 26
Citations - 5507
Biju Issac is an academic researcher from University of Miami. The author has contributed to research in topics: Gene & Cellular differentiation. The author has an hindex of 13, co-authored 24 publications receiving 5168 citations. Previous affiliations of Biju Issac include Henry M. Jackson Foundation for the Advancement of Military Medicine & Broad Institute.
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Journal ArticleDOI
Genome-wide maps of chromatin state in pluripotent and lineage-committed cells
Tarjei S. Mikkelsen,Manching Ku,Manching Ku,David B. Jaffe,Biju Issac,Biju Issac,Erez Lieberman Aiden,Erez Lieberman Aiden,Georgia Giannoukos,Pablo Alvarez,William Brockman,Tae Kyung Kim,Richard Koche,Richard Koche,Richard Koche,William Lee,Eric M. Mendenhall,Eric M. Mendenhall,Aisling O'Donovan,Aviva Presser,Carsten Russ,Xiaohui Xie,Alexander Meissner,Marius Wernig,Rudolf Jaenisch,Chad Nusbaum,Eric S. Lander,Eric S. Lander,Bradley E. Bernstein,Bradley E. Bernstein +29 more
TL;DR: The application of single-molecule-based sequencing technology for high-throughput profiling of histone modifications in mammalian cells is reported and it is shown that chromatin state can be read in an allele-specific manner by using single nucleotide polymorphisms.
Journal ArticleDOI
GC-Rich Sequence Elements Recruit PRC2 in Mammalian ES Cells
Eric M. Mendenhall,Richard Koche,Thanh Truong,Thanh Truong,Thanh Truong,Vicky Weijie Zhou,Biju Issac,Biju Issac,Biju Issac,Andrew S. Chi,Manching Ku,Manching Ku,Manching Ku,Bradley E. Bernstein,Bradley E. Bernstein,Bradley E. Bernstein +15 more
TL;DR: In this paper, a series of engineered bacterial artificial chromosomes were integrated into embryonic stem (ES) cells and examined their chromatin, and it was shown that a 44 kb region corresponding to the Zfpm2 locus initiates de novo recruitment of PRC2.
GC-rich sequence elements recruit PRC2 in mammalian ES cells
Thanh Truong,Biju Issac,Eric M. Mendenhall,Richard Koche,Vicky Weijie Zhou,Andrew S. Chi,Manching Ku,Bradley E. Bernstein +7 more
TL;DR: A causal role for GC-rich sequences in PRC2 recruitment is demonstrated and a specific subset of CpG islands depleted of activating motifs are implicate as instrumental for the initial localization of this key regulator in mammalian genomes.
Journal ArticleDOI
Spectral Repeat Finder (SRF): identification of repetitive sequences using Fourier transformation
TL;DR: The Spectral Repeat Finder program circumvents problems by using a discrete Fourier transformation to identify significant periodicities present in a sequence and shows efficient and complete detection of repeats.
Journal ArticleDOI
CD11b activation suppresses TLR-dependent inflammation and autoimmunity in systemic lupus erythematosus
Mohd Hafeez Faridi,Samia Q. Khan,Wenpu Zhao,Ha Won Lee,Mehmet M. Altintas,Kun Zhang,Vinay Kumar,Andrew Armstrong,Carmelo Carmona-Rivera,Jessica M. Dorschner,Abigail M. Schnaith,Xiaobo Li,Yogita Ghodke-Puranik,Erica Moore,Monica M. Purmalek,Jorge A Irizarry-Caro,Tingting Zhang,Rachael Day,Darren Stoub,Victoria Hoffmann,Shehryar Jehangir Khaliqdina,Prachal Bhargava,Ana M. Santander,Marta Torroella-Kouri,Biju Issac,David Cimbaluk,Andrew Zloza,Rajeev Prabhakar,Shashank Deep,Meenakshi Jolly,Kwi Hye Koh,Jonathan S. Reichner,Elizabeth M. Bradshaw,JianFeng Chen,Luis F. Moita,Peter S.T. Yuen,Wanxia Li Tsai,Bhupinder Singh,Jochen Reiser,Swapan K. Nath,Timothy B. Niewold,Roberto I. Vazquez-Padron,Mariana J. Kaplan,Vineet Gupta +43 more
TL;DR: CD11b activation reduced TLR-dependent proinflammatory signaling in leukocytes and suppressed IFN-I signaling via an AKT/FOXO3/IFN regulatory factor 3/7 pathway, and pharmacologic activation of CD11b could be a potential mechanism for developing SLE therapeutics.