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Bikas C. Pal

Bio: Bikas C. Pal is an academic researcher from Indian Institute of Chemical Biology. The author has contributed to research in topics: Androsace & Apoptosis. The author has an hindex of 16, co-authored 26 publications receiving 703 citations.

Papers
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Journal ArticleDOI
TL;DR: The role of ROS was established in Chl-mediated preferential killing of Bcr-Abl(+) cells with primary leukemia cells from CML patients in vitro as well as in vivo in nude mice bearing K562 xenografts, confirming the involvement of parallel death pathways that converged in mitochondria.

93 citations

Journal ArticleDOI
TL;DR: The methanolic extract of Dillenia indica L. fruits showed significant anti-leukemic activity in human leukemic cell lines U937, HL60 and K562, and a major compound, betulinic acid, was isolated from the ethyl acetate fraction by silica gel column chromatography and was identified and characterized.

92 citations

Journal ArticleDOI
TL;DR: Three main saponins named albiziasaponins A, B, and C were isolated from the barks of Albizia lebbeck through spectral analyses as acacic acid lactone, 3-O-beta-D-xylopyranosyl-(1-->2)-alpha-L-arabinopyrnosyl-( 1-->6)- beta-D

78 citations

Journal ArticleDOI
TL;DR: It is demonstrated for the first time that mahanine can reverse an epigenetically silenced gene, RASSF1A in prostate cancer cells by inhibiting DNMT activity that in turn down-regulates a key cell cycle regulator, cyclin D1.

66 citations

Journal ArticleDOI
TL;DR: It is demonstrated that methanol-aqueous fraction (MAF2) of Cajanus cajan leaf extract could prevent the chronically treated alcohol induced rat liver damage and shows a promise in therapeutic use in alcohol induced liver dysfunction.

59 citations


Cited by
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Journal ArticleDOI
TL;DR: In this review, the most recent findings in the oxidative stress field are described, highlighting both its bad and good sides for human health.
Abstract: Oxidative stress is a phenomenon caused by an imbalance between production and accumulation of oxygen reactive species (ROS) in cells and tissues and the ability of a biological system to detoxify these reactive products. ROS can play, and in fact they do it, several physiological roles (i.e., cell signaling), and they are normally generated as by-products of oxygen metabolism; despite this, environmental stressors (i.e., UV, ionizing radiations, pollutants, and heavy metals) and xenobiotics (i.e., antiblastic drugs) contribute to greatly increase ROS production, therefore causing the imbalance that leads to cell and tissue damage (oxidative stress). Several antioxidants have been exploited in recent years for their actual or supposed beneficial effect against oxidative stress, such as vitamin E, flavonoids, and polyphenols. While we tend to describe oxidative stress just as harmful for human body, it is true as well that it is exploited as a therapeutic approach to treat clinical conditions such as cancer, with a certain degree of clinical success. In this review, we will describe the most recent findings in the oxidative stress field, highlighting both its bad and good sides for human health.

1,810 citations

Journal ArticleDOI
TL;DR: In this paper, a compilation of the 13C NMR data of a selected variety of naturally occurring pentacyclic triterpenoids, arranged skeletonwise, is provided.

1,251 citations

Journal Article
TL;DR: The PEE of the seed of Pongomia pinnata was further tested for nootropic activity in an experimental model of Alzheimer’s disease and reversed both, the cognitive deficits and the reduction in cholinergic markers after 2 weeks of treatment.
Abstract: time, probably by stimulation of the hepatic microsomal enzyme system3. Similar properties were exhibited by its roots. However, the petroleum ether extract (PEE) of the roots enhanced pentobarbitone sleeping time, probably due to CNS depression4. The PEE of the seed of Pongomia pinnata was further tested for nootropic activity in an experimental model of Alzheimer’s disease (created by ibotenic acid induced lesioning of nuclear basalis magnocellularis). It reversed both, the cognitive deficits and the reduction in cholinergic markers after 2 weeks of treatment. Reversal of perturbed cholinergic function appears to be the possible mechanism5.

612 citations

Journal ArticleDOI
TL;DR: ROS act as a double-edged sword, similar to tumor necrosis factor-α, inflammation, and NF-κB, which provides a great challenge for researchers whose aim is to exploit ROS stress for the development of cancer therapies.
Abstract: Significance: Extensive research during the last quarter century has revealed that reactive oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role in various cell-signaling pathways. Most risk factors associated with chronic diseases (e.g., cancer), such as stress, tobacco, environmental pollutants, radiation, viral infection, diet, and bacterial infection, interact with cells through the generation of ROS. Recent Advances: ROS, in turn, activate various transcription factors (e.g., nuclear factor kappa-light-chain-enhancer of activated B cells [NF-κB], activator protein-1, hypoxia-inducible factor-1α, and signal transducer and activator of transcription 3), resulting in the expression of proteins that control inflammation, cellular transformation, tumor cell survival, tumor cell proliferation and invasion, angiogenesis, and metastasis. Paradoxically, ROS also control the expression of various tumor suppressor genes (p53, Rb, and PTEN). Similarly, γ-radiation and various chemotherapeutic agents used to treat cancer mediate their effects through the production of ROS. Interestingly, ROS have also been implicated in the chemopreventive and anti-tumor action of nutraceuticals derived from fruits, vegetables, spices, and other natural products used in traditional medicine. Critical Issues: These statements suggest both “upside” (cancer-suppressing) and “downside” (cancer-promoting) actions of the ROS. Thus, similar to tumor necrosis factor-α, inflammation, and NF-κB, ROS act as a double-edged sword. This paradox provides a great challenge for researchers whose aim is to exploit ROS stress for the development of cancer therapies. Future Directions: The various mechanisms by which ROS mediate paradoxical effects are discussed in this article. The outstanding questions and future directions raised by our current understanding are discussed. Antioxid. Redox Signal. 16, 1295–1322.

605 citations