B
Bilge Argunhan
Researcher at Tokyo Institute of Technology
Publications - 26
Citations - 362
Bilge Argunhan is an academic researcher from Tokyo Institute of Technology. The author has contributed to research in topics: Homologous recombination & RAD51. The author has an hindex of 8, co-authored 24 publications receiving 272 citations. Previous affiliations of Bilge Argunhan include University of Sussex & Queen Mary University of London.
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Journal ArticleDOI
The Ecm11-Gmc2 complex promotes synaptonemal complex formation through assembly of transverse filaments in budding yeast.
Neil Humphryes,Wing-Kit Leung,Bilge Argunhan,Yaroslav Terentyev,Martina Dvorackova,Hideo Tsubouchi +5 more
TL;DR: The Ecm11-Gmc2 complex is a novel SC component, functioning to facilitate assembly of the yeast transverse filament protein, Zip1, and it is proposed that SUMOylation of Ecm 11 is critical for ensuring chromosomal assembly of Zip 1, thus suppressing polycomplex formation.
Journal ArticleDOI
Fundamental cell cycle kinases collaborate to ensure timely destruction of the synaptonemal complex during meiosis.
Bilge Argunhan,Bilge Argunhan,Wing Kit Leung,Negar Afshar,Negar Afshar,Yaroslav Terentyev,Vijayalakshmi V. Subramanian,Yasuto Murayama,Andreas Hochwagen,Hiroshi Iwasaki,Tomomi Tsubouchi,Hideo Tsubouchi,Hideo Tsubouchi +12 more
TL;DR: It is proposed that the concerted action of DDK, Polo‐like kinase, and CDK1 promotes efficient SC destruction at the end of prophase I to ensure faithful inheritance of the genome.
Journal ArticleDOI
The synaptonemal complex is assembled by a polySUMOylation-driven feedback mechanism in yeast
Wing-Kit Leung,Neil Humphryes,Negar Afshar,Bilge Argunhan,Yaroslav Terentyev,Tomomi Tsubouchi,Hideo Tsubouchi +6 more
TL;DR: Researchers have shown that the N terminus of Zip1 activates Ecm11 polySUMOylation, suggesting that this positive feedback loop underpins SC assembly.
Journal ArticleDOI
Budding yeast Pch2, a widely conserved meiotic protein, is involved in the initiation of meiotic recombination
Sarah Farmer,Eun Jin Erica Hong,Wing Kit Leung,Bilge Argunhan,Yaroslav Terentyev,Neil Humphryes,Hiroshi Toyoizumi,Hiroshi Toyoizumi,Hideo Tsubouchi +8 more
TL;DR: Evidence is presented that Pch2 is involved in meiotic DSB formation, the initiation step of meiotic recombination, which is necessary for igniting the subsequent meiotic checkpoint responses that lead to proper differentiation of meiosis recombinants.
Journal ArticleDOI
Direct and indirect control of the initiation of meiotic recombination by DNA damage checkpoint mechanisms in budding yeast.
Bilge Argunhan,Sarah Farmer,Wing Kit Leung,Yaroslav Terentyev,Neil Humphryes,Tomomi Tsubouchi,Hiroshi Toyoizumi,Hideo Tsubouchi +7 more
TL;DR: It is proposed that, within prophase I, the Tel1 pathway facilitates D SB formation, especially in bigger chromosomes, while the Mec1 pathway negatively regulates DSB formation.