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Bin Ju
Researcher at Southern University of Science and Technology
Publications - 35
Citations - 2361
Bin Ju is an academic researcher from Southern University of Science and Technology. The author has contributed to research in topics: Antibody & Medicine. The author has an hindex of 7, co-authored 14 publications receiving 1371 citations.
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Journal ArticleDOI
Human neutralizing antibodies elicited by SARS-CoV-2 infection.
Bin Ju,Qi Zhang,Jiwan Ge,Ruoke Wang,Jing Sun,Xiangyang Ge,Jiazhen Yu,Sisi Shan,Bing Zhou,Shuo Song,Xian Tang,Jinfang Yu,Jun Lan,Jing Yuan,Haiyan Wang,Juanjuan Zhao,Shuye Zhang,Youchun Wang,Xuanling Shi,Lei Liu,Jincun Zhao,Xinquan Wang,Zheng Zhang,Linqi Zhang +23 more
TL;DR: In a study of antibodies isolated from patients infected with SARS-CoV-2, antibodies that potently neutralized the virus competed with angiotensin-converting enzyme 2 for binding to the receptor-binding domain of the viral spike protein, suggesting that antibodies that disrupt this interaction could be developed to treat Sars-Cov-2 infection.
Posted ContentDOI
Potent human neutralizing antibodies elicited by SARS-CoV-2 infection
Bin Ju,Qi Zhang,Ruoke Wang,Sisi Shan,Jinfang Yu,Jiwan Ge,Jun Lan,Shuye Zhang,Youchun Wang,Xuanling Shi,Xinquan Wang,Linqi Zhang +11 more
TL;DR: Results suggest that antibody response to RBDs is viral species-specific while that cross-recognition target regions outside the RBD are cross- Recognition target areas outside the SARS-CoV-2.
Journal ArticleDOI
Analysis of SARS-CoV-2 variant mutations reveals neutralization escape mechanisms and the ability to use ACE2 receptors from additional species.
Ruoke Wang,Qi Zhang,Jiwan Ge,Wenlin Ren,Rui Zhang,Jun Lan,Bin Ju,Bin Su,Fengting Yu,Peng Chen,Huiyu Liao,Yingmei Feng,Xuemei Li,Xuanling Shi,Zheng Zhang,Fujie Zhang,Qiang Ding,Qiang Ding,Tong Zhang,Xinquan Wang,Linqi Zhang,Linqi Zhang +21 more
TL;DR: In this article, the authors showed that the South African variant B.1.351 was the most resistant to current monoclonal antibodies and convalescent plasma from coronavirus disease 2019 (COVID-19)-infected individuals.
Journal ArticleDOI
Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry.
Jiwan Ge,Ruoke Wang,Bin Ju,Qi Zhang,Jing Sun,Peng Chen,Senyan Zhang,Yuling Tian,Sisi Shan,Lin Cheng,Bing Zhou,Shuo Song,Juanjuan Zhao,Haiyan Wang,Xuanling Shi,Qiang Ding,Lei Liu,Jincun Zhao,Zheng Zhang,Xinquan Wang,Linqi Zhang +20 more
TL;DR: In this paper, the top three most potent yet variable neutralizing antibodies for SARS-CoV-2 infection in Ad5-hACE2-sensitized mice were identified.
Journal ArticleDOI
Potent and protective IGHV3-53/3-66 public antibodies and their shared escape mutant on the spike of SARS-CoV-2.
Qi Zhang,Bin Ju,Jiwan Ge,Jasper Fuk-Woo Chan,Jasper Fuk-Woo Chan,Lin Cheng,Ruoke Wang,Weijin Huang,Mengqi Fang,Peng Chen,Bing Zhou,Shuo Song,Sisi Shan,Baohua Yan,Senyan Zhang,Xiangyang Ge,Jiazhen Yu,Juanjuan Zhao,Haiyan Wang,Li Liu,Qining Lv,Lili Fu,Xuanling Shi,Kwok-Yung Yuen,Kwok-Yung Yuen,Lei Liu,Youchun Wang,Zhiwei Chen,Zhiwei Chen,Linqi Zhang,Xinquan Wang,Zheng Zhang +31 more
TL;DR: In this article, a total of 165 antibodies from eight SARS-CoV-19 patients were examined and found that potent nAbs from different patients have disproportionally high representation of IGHV3-53/3-66 usage, and therefore termed as public antibodies.