Bin Liu

Bio: Bin Liu is an academic researcher from Central South University. The author has contributed to research in topics: Microstructure & Alloy. The author has an hindex of 72, co-authored 871 publications receiving 24219 citations. Previous affiliations of Bin Liu include Chinese Ministry of Education & Max Planck Society.

Regulation of JAK–STAT signalling in the immune system

Abstract: The cytokine-activated Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway has an important role in the control of immune responses. Dysregulation of JAK–STAT signalling is associated with various immune disorders. The signalling strength, kinetics and specificity of the JAK–STAT pathway are modulated at many levels by distinct regulatory proteins. Here, we review recent studies on the regulation of the JAK–STAT pathway that will enhance our ability to design rational therapeutic strategies for immune diseases.

Specific Inhibition of Stat3 Signal Transduction by PIAS3

Abstract: The signal transducer and activator of transcription–3 (Stat3) protein is activated by the interleukin 6 (IL-6) family of cytokines, epidermal growth factor, and leptin. A protein named PIAS3 (protein inhibitor of activated STAT) that binds to Stat3 was isolated and characterized. The association of PIAS3 with Stat3 in vivo was only observed in cells stimulated with ligands that cause the activation of Stat3. PIAS3 blocked the DNA-binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.

Inhibition of Stat1-mediated gene activation by PIAS1.

Abstract: STAT (signal transducer and activator of transcription) proteins are latent cytoplasmic transcription factors that become activated by tyrosine phosphorylation in response to cytokine stimulation Tyrosine phosphorylated STATs dimerize and translocate into the nucleus to activate specific genes Different members of the STAT protein family have distinct functions in cytokine signaling Biochemical and genetic analysis has demonstrated that Stat1 is essential for gene activation in response to interferon stimulation Although progress has been made toward understanding STAT activation, little is known about how STAT signals are down-regulated We report here the isolation of a family of PIAS (protein inhibitor of activated STAT) proteins PIAS1, but not other PIAS proteins, blocked the DNA binding activity of Stat1 and inhibited Stat1-mediated gene activation in response to interferon Coimmunoprecipitation analysis showed that PIAS1 was associated with Stat1 but not Stat2 or Stat3 after ligand stimulation The in vivo PIAS1-Stat1 interaction requires phosphorylation of Stat1 on Tyr-701 These results identify PIAS1 as a specific inhibitor of Stat1-mediated gene activation and suggest that there may exist a specific PIAS inhibitor in every STAT signaling pathway

High-Level Synthesis for FPGAs: From Prototyping to Deployment

Abstract: Escalating system-on-chip design complexity is pushing the design community to raise the level of abstraction beyond register transfer level. Despite the unsuccessful adoptions of early generations of commercial high-level synthesis (HLS) systems, we believe that the tipping point for transitioning to HLS msystem-on-chip design complexityethodology is happening now, especially for field-programmable gate array (FPGA) designs. The latest generation of HLS tools has made significant progress in providing wide language coverage and robust compilation technology, platform-based modeling, advancement in core HLS algorithms, and a domain-specific approach. In this paper, we use AutoESL's AutoPilot HLS tool coupled with domain-specific system-level implementation platforms developed by Xilinx as an example to demonstrate the effectiveness of state-of-art C-to-FPGA synthesis solutions targeting multiple application domains. Complex industrial designs targeting Xilinx FPGAs are also presented as case studies, including comparison of HLS solutions versus optimized manual designs. In particular, the experiment on a sphere decoder shows that the HLS solution can achieve an 11-31% reduction in FPGA resource usage with improved design productivity compared to hand-coded design.

I and i

Abstract: There is, I think, something ethereal about i —the square root of minus one. I remember first hearing about it at school. It seemed an odd beast at that time—an intruder hovering on the edge of reality. Usually familiarity dulls this sense of the bizarre, but in the case of i it was the reverse: over the years the sense of its surreal nature intensified. It seemed that it was impossible to write mathematics that described the real world in …

Fast parallel algorithms for short-range molecular dynamics

Abstract: Three parallel algorithms for classical molecular dynamics are presented. The first assigns each processor a fixed subset of atoms; the second assigns each a fixed subset of inter-atomic forces to compute; the third assigns each a fixed spatial region. The algorithms are suitable for molecular dynamics models which can be difficult to parallelize efficiently—those with short-range forces where the neighbors of each atom change rapidly. They can be implemented on any distributed-memory parallel machine which allows for message-passing of data between independently executing processors. The algorithms are tested on a standard Lennard-Jones benchmark problem for system sizes ranging from 500 to 100,000,000 atoms on several parallel supercomputers--the nCUBE 2, Intel iPSC/860 and Paragon, and Cray T3D. Comparing the results to the fastest reported vectorized Cray Y-MP and C90 algorithm shows that the current generation of parallel machines is competitive with conventional vector supercomputers even for small problems. For large problems, the spatial algorithm achieves parallel efficiencies of 90% and a 1840-node Intel Paragon performs up to 165 faster than a single Cray C9O processor. Trade-offs between the three algorithms and guidelines for adapting them to more complex molecular dynamics simulations are also discussed.

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Abstract: 抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

A draft sequence of the rice genome (Oryza sativa L. ssp indica)

Abstract: We have produced a draft sequence of the rice genome for the most widely cultivated subspecies in China, Oryza sativa L. ssp. indica, by whole-genome shotgun sequencing. The genome was 466 megabases in size, with an estimated 46,022 to 55,615 genes. Functional coverage in the assembled sequences was 92.0%. About 42.2% of the genome was in exact 20-nucleotide oligomer repeats, and most of the transposons were in the intergenic regions between genes. Although 80.6% of predicted Arabidopsis thaliana genes had a homolog in rice, only 49.4% of predicted rice genes had a homolog in A. thaliana. The large proportion of rice genes with no recognizable homologs is due to a gradient in the GC-content of rice coding sequences.