B
Bin Zhan
Researcher at Baylor College of Medicine
Publications - 155
Citations - 5147
Bin Zhan is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Antigen & Necator americanus. The author has an hindex of 36, co-authored 141 publications receiving 4347 citations. Previous affiliations of Bin Zhan include Boston Children's Hospital & Washington University in St. Louis.
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Journal ArticleDOI
Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals
Jeffrey M. Bethony,Alex Loukas,Michael J. Smout,Simon Brooker,Susana Mendez,Jordan L. Plieskatt,Gaddam Goud,Maria Elena Bottazzi,Bin Zhan,Yan Wang,Angela L. Williamson,Sara Lustigman,Rodrigo Correa-Oliveira,Shu-Hua Xiao,Peter J. Hotez +14 more
TL;DR: Support is provided for the development of an effective recombinant vaccine against hookworm infection in humans by examining the antibody responses of individuals from hookworm endemic areas of Brazil and China against the most abundant L3 secreted antigens, the ancylostoma secreted proteins, ASP‐1 and ASP‐2.
Journal ArticleDOI
Genome of the human hookworm Necator americanus
Yat T. Tang,Xin Gao,Bruce A. Rosa,Sahar Abubucker,Kymberlie Hallsworth-Pepin,John Martin,Rahul Tyagi,Esley M. Heizer,Xu Zhang,Veena Bhonagiri-Palsikar,Patrick Minx,Wesley C. Warren,Qi Wang,Bin Zhan,Peter J. Hotez,Paul W. Sternberg,Paul W. Sternberg,Annette M. Dougall,Soraya Gaze,Jason Mulvenna,Javier Sotillo,Shoba Ranganathan,Shoba Ranganathan,Élida Mara Leite Rabelo,Richard K. Wilson,Philip L. Felgner,Jeffrey M. Bethony,John M. Hawdon,Robin B. Gasser,Alex Loukas,Makedonka Mitreva +30 more
TL;DR: Characterization of this first hookworm genome sequence identified genes orchestrating the hookworm's invasion of the human host, genes involved in blood feeding and development, and genes encoding proteins that represent new potential drug targets against hookworms.
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Emerging Patterns of Hookworm Infection: Influence of Aging on the Intensity of Necator Infection in Hainan Province, People's Republic of China
Jeffrey M. Bethony,Jizhang Chen,Shaoxiong Lin,Shu-Hua Xiao,Bin Zhan,Shangwen Li,Hai-chou Xue,Fuying Xing,Debbie Humphries,Wang Yan,Grace Chen,Virginia Foster,John M. Hawdon,Peter J. Hotez +13 more
TL;DR: Age and sex made the most important contributions to the variation in infection intensity, and the importance of aging in Necator infection reveals an emerging public health problem among the elderly population of developing countries.
Journal ArticleDOI
Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative.
Peter J. Hotez,Bin Zhan,Jeffrey M. Bethony,Alex Loukas,Angela L. Williamson,Gaddam Goud,John M. Hawdon,Azra Dobardzic,Reshad Dobardzic,Kashinath Ghosh,Maria Elena Bottazzi,Susana Mendez,Bernard C. Zook,Yan Wang,Sen Liu,Sen Liu,Idong Essiet-Gibson,Sophia Chung-Debose,Shu-Hua Xiao,David P. Knox,Michael M. Meagher,Mehmet Inan,Rodrigo Correa-Oliveira,Paul Vilk,Herman R Shepherd,Walter E. Brandt,Philip K. Russell +26 more
TL;DR: Despite the inability of the human host to develop naturally acquired immune responses to hookworm, there is evidence for the feasibility of developing a vaccine based on the successes of immunising laboratory animals with either attenuated larval vaccines or antigens extracted from the alimentary canal of adult blood-feeding stages
Journal ArticleDOI
X-ray structure of Na-ASP-2, a pathogenesis-related-1 protein from the nematode parasite, Necator americanus, and a vaccine antigen for human hookworm infection
Oluwatoyin A. Asojo,Gaddam Goud,Kajari Dhar,Alex Loukas,Alex Loukas,Bin Zhan,Vehid Deumic,Sen Liu,Gloria E. O. Borgstahl,Peter J. Hotez +9 more
TL;DR: A novel crystal structure of Na-ASP-2, a PR-1 protein secreted by infective larvae of the human hookworm Necator americanus, has been solved and may shed light on the molecular basis of host-parasite interactions.