Bin Zhou

TL;DR: A biologist-oriented portal that provides a gene list annotation, enrichment and interactome resource and enables integrated analysis of multi-OMICs datasets, Metascape is an effective and efficient tool for experimental biologists to comprehensively analyze and interpret OMICs-based studies in the big data era.

TL;DR: A novel cardiogenic precursor marked by expression of the transcription factor Wt1 and located within the epicardium—an epithelial sheet overlying the heart is identified and identified as previously unrecognized cardiomyocyte progenitors.

TL;DR: It is demonstrated in mice that the adult heart contains a resident stem or progenitor cell population, which has the potential to contribute bona fide terminally differentiated cardiomyocytes after myocardial infarction and is shown to structurally and functionally integrate with resident muscle.

TL;DR: The role of long noncoding RNA (lncRNA) in adult heart is unknown; also unclear is how lncRNA modulates nucleosome remodelling as discussed by the authors. But they identify a cluster of LncRNA transcripts from myosin heavy chain 7 (Myh7) loci and demonstrate a new lnc RNA-chromatin mechanism for heart failure.

TL;DR: Following pressure overload, fibroblasts were not derived from hematopoietic cells, EndoMT, or epicardial epithelial-to-mesenchymal transition; instead, pressure overload promoted comparable proliferation and activation of two resident fibroblast lineages, including a previously described epicardsial population and a population of endothelial origin.