Bing Zhao

TL;DR: It is proposed that chromatin interactions constitute a primary mechanism for regulating transcription in mammalian genomes and is described as a new strategy, chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) for the de novo detection of global Chromatin interactions.

TL;DR: In this article, the authors examined whether ER binding sites that are located distal from the transcription start sites of estrogen target genes are functionally relevant and found that ERs occupied at the distal sites are capable of communicating with ERs bound at the proximal promoter region, possibly via long range chromosome looping.

TL;DR: The data indicate that distal ER binding sites are bona fide transcriptional enhancers that are involved in long range chromosomal interaction, transcription complex formation, and distinct structural modifications of chromatin across large genomic spans.

TL;DR: In this paper , a large scale untargeted metabolomics approach was employed in T. grandis nuts, revealing for a total of 140 differential accumulated metabolites, nearly 60% of metabolites belonging to terpenoids, coumarins and phenolic acids, and phytohormones were showed a gradual accumulation pattern, while most of compounds in flavonoids were decreased during post-ripening.