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Birgit Simell
Researcher at National Institutes of Health
Publications - 18
Citations - 1215
Birgit Simell is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Pneumococcal infections & Pneumococcal conjugate vaccine. The author has an hindex of 13, co-authored 17 publications receiving 1069 citations. Previous affiliations of Birgit Simell include University of Helsinki.
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The fundamental link between pneumococcal carriage and disease
TL;DR: A review of the evidence supporting pneumococcal carriage at the individual level as an immediate and necessary precursor to pneumonia disease is provided in this article, where the authors emphasize the role of information on vaccine carriage in vaccine trials and in public health decision-making.
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Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis
Birgit Simell,Arja Vuorela,Nina Ekström,Arto A. Palmu,Antti Reunanen,Seppo Meri,Helena Käyhty,Merja Väkeväinen +7 more
TL;DR: The reduced functional activity of serotype-specific antibodies and the compromised function of neutrophils in the opsonophagocytosis of pneumococci are likely to contribute to the increased susceptibility of the elderly to pneumococcal diseases.
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Effects of Ageing and Gender on Naturally Acquired Antibodies to Pneumococcal Capsular Polysaccharides and Virulence-Associated Proteins
TL;DR: The concentrations of naturally acquired antibodies to pneumococcal capsular polysaccharides and protein antigens were significantly lower in the elderly than in younger adults, and a stronger decline in anti-PPS antibody concentrations was seen with age in women compared to men.
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Pneumococcal Carriage and Otitis Media Induce Salivary Antibodies to Pneumococcal Surface Adhesin A, Pneumolysin, and Pneumococcal Surface Protein A in Children
TL;DR: The findings indicate that pneumococcal carriage and AOM induce local production of anti-PsaA, anti-ply, andAnti-PspA antibodies early in life.
The fundamental link between pneumococcal carriage and disease
TL;DR: The use of vaccine effect on carriage as part of the vaccine licensure and post-vaccine introduction evaluation could facilitate and expand the licensure of new, life-saving pneumococcal vaccines and enable a comprehensive estimate of population effects after vaccine introduction.