Biswanath De

TL;DR: Functional studies with AT1-antagonists indicate that Ang II antagonism at the receptor level can be rather complex, and experimental data suggests that not only are receptor binding kinetics involved, but also that additional binding sites, and possibly even AT1 subtypes, are involved.

TL;DR: MMP inhibitors are partially protective against cartilage and subchondral bone damage induced by iodoacetate and support an important role for MMPs in mediating the joint damage in this model of arthritis.

TL;DR: 2-Aryl-3-pyrimidinyl based tumor necrosis factor-alpha (TNF-alpha) inhibitors, which contain a novel bicyclic pyrazolone core, showed good oral bioavailability in rat and efficacy in the rat iodoacetate in vivo model.

TL;DR: A new generation of cyclic matrix metalloproteinase (MMP) inhibitors derived from dl-piperazinecarboxylic acid has been described, with unique combination of all three elements producing inhibitor 20 with high affinity for MMPs 1, 3, 9, and 13.

TL;DR: The synthesis and enzyme inhibition data for a series of thiazine- and thiazepine-based matrix metalloproteinase (MMP) inhibitors are described and the most potent series of inhibitors was obtained by modification of the amino acid D-penicillamine.