B
Blaz Lupse
Researcher at University of Bremen
Publications - 12
Citations - 475
Blaz Lupse is an academic researcher from University of Bremen. The author has contributed to research in topics: mTORC1 & Downregulation and upregulation. The author has an hindex of 7, co-authored 12 publications receiving 298 citations.
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Journal ArticleDOI
mTORC1 Signaling: A Double-Edged Sword in Diabetic β Cells.
TL;DR: It is suggested that mTORC1 may act as a "double edge sword" in the regulation of β cell mass and function in response to metabolic stress such as nutrient overload and insulin resistance.
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Hippo Signaling: Key Emerging Pathway in Cellular and Whole-Body Metabolism.
TL;DR: The emerging function of Hippo in the regulation of metabolic homeostasis under physiological and pathological conditions is highlighted and how this interplay regulates cellular metabolism and metabolic pathways is summarized.
Journal ArticleDOI
Reciprocal regulation of mTOR complexes in pancreatic islets from humans with type 2 diabetes
Ting Yuan,Sahar Rafizadeh,Kanaka Durga Devi Gorrepati,Blaz Lupse,Jose Oberholzer,Kathrin Maedler,Amin Ardestani +6 more
TL;DR: Elevated mTORC1 activation is a striking pathogenic hallmark of islets in type 2 diabetes, contributing to impaired beta cell function and survival in the presence of metabolic stress and under high-glucose conditions in metabolically stressed human islets.
Journal ArticleDOI
Neratinib protects pancreatic beta cells in diabetes
Amin Ardestani,Sijia Li,Karthika Annamalai,Blaz Lupse,Shirin Geravandi,Aleksandra Dobrowolski,Shan Yu,Siying Zhu,Tyler D. Baguley,Murali Mohan Reddy Peram Surakattula,Janina Oetjen,Lena Hauberg-Lotte,Raquel Herranz,Sushil Awal,Delsi Altenhofen,Van Nguyen-Tran,Sean B. Joseph,Peter G. Schultz,Arnab K. Chatterjee,Nikki Rogers,Matthew S. Tremblay,Weijun Shen,Kathrin Maedler +22 more
TL;DR: Neratinib is a previously unrecognized inhibitor of MST1 and represents a potential β-cell-protective drug with proof-of-concept in vitro in human islets and in vivo in rodent models of both type 1 and type 2 diabetes.
Journal ArticleDOI
mTORC2 Signaling: A Path for Pancreatic β Cell's Growth and Function.
TL;DR: Recent emerging advances on the contribution of mTORC2 and its associated signaling on the regulation of glucose metabolism and functional β-cell mass under physiological and pathophysiological conditions in type 2 diabetes are summarized.