Author
Bobbak Vahid
Bio: Bobbak Vahid is an academic researcher from Thomas Jefferson University. The author has contributed to research in topics: Pneumonia & Hypersensitivity pneumonitis. The author has an hindex of 9, co-authored 42 publications receiving 1383 citations.
Papers
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TL;DR: A systematic review of the literature demonstrated a very poor relationship between CVP and blood volume as well as the inability of CVP/DeltaCVP to predict the hemodynamic response to a fluid challenge.
1,295 citations
TL;DR: Different pulmonary syndromes, pathogenesis and management of these novel agents in patients with hematological malignancies are discussed.
Abstract: Infiltrative lung disease is a well-known complication of antineoplastic agents in patients with hematological malignancies. Novel agents are constantly being added to available treatments. The present review discusses different pulmonary syndromes, pathogenesis and management of these novel agents.
23 citations
TL;DR: Two patients started on erlotinib treatment for metastatic non-small cell lung cancer developed acute pneumonitis and the first patient died of Klebsiella sepsis, while the second patient improved gradually and finally was discharged to a rehabilitation centre.
Abstract: Two cases of erlotinib-associated acute pneumonitis are described. The first patient was started on erlotinib treatment for metastatic non-small cell lung cancer. The second patient was treated with erlotinib for metastatic adenocarcinoma of unknown origin. Both patients developed dyspnea and hypoxemia five to six days after initiation of erlotinib treatment. In both cases, computed tomography scan of the chest showed extensive bilateral ground-glass infiltrates consistent with pneumonitis. In both patients, acute pneumonitis resulted in respiratory failure requiring intubation and mechanical ventilation. Diffuse alveolar hemorrhage was excluded by bronchoscopy in both cases. Bronchoalveolar lavage cultures were negative. Erlotinib treatment was stopped and both patients were treated with corticosteroids. The first patient improved gradually and finally was discharged to a rehabilitation centre, but unfortunately the second patient died of Klebsiella sepsis. Naranjo causality scale in both cases suggested a probable association between erlotinib and pneumonitis. Literature on erlotinib-associated pneumonitis is sparse. The clinical presentation and radiographic findings of erlotinib-associated acute pneumonitis are described.
23 citations
TL;DR: In this article, the authors described three patients with established diagnosis of sarcoidosis that developed skin lesions consistent with NLD, which is a granulomatous skin disease mostly associated with diabetes mellitus.
18 citations
TL;DR: The case of a 33-year-old African-American male who presented with multiple deep venous thromboses of the upper and lower extremities and sarcoidosis is described, and lymph node histopathologic examination showed noncaseating granulomas.
Abstract: We describe the case of a 33-year-old African-American male who presented with multiple deep venous thromboses of the upper and lower extremities. Hypercoagulable workup was unrevealing. A chest x-ray showed bilateral hilar lymph node enlargement. Mediastinoscopy with hilar lymph node biopsy was performed. Lymph node histopathologic examination showed noncaseating granulomas. Lymph node tissue culture and special stains were negative for mycobacterial or fungal infection. This is an unusual case of multiple deep venous thromboses and sarcoidosis. The subject of sarcoidosis and venous thrombosis is discussed.
13 citations
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Journal Article•
3,097 citations
TL;DR: Evidence-based recommendations are provided for the diagnosis and management of acute decompensated heart failure including morphine, high-dose diuretics, and inotropic agents may be harmful.
Abstract: Acute decompensated heart failure (ADHF) is the most common reason for hospitalization in Western nations. The prognosis of patients admitted to hospital with ADHF is poor, with up to 64% being readmitted within the first 90 days after discharge and with a 1-year mortality approximating 20%. Epidemiological studies suggest that the majority of patients hospitalized with ADHF receive treatment that is inadequate and which is not based on scientific evidence. Furthermore, emerging data suggest that the "conventional" therapeutic interventions for ADHF including morphine, high-dose diuretics, and inotropic agents may be harmful. The goal of this review is to provide evidence-based recommendations for the diagnosis and management of ADHF.
2,472 citations
DOI•
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05 Nov 2009
TL;DR: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此第一印象中拟诊 结核5例,为此应引起临床对本 病诊
Abstract: 结节病易误诊,据王洪武等~([1])收集国内18篇关于此病误诊的文献,误诊率高达63.2%,当然有误诊就会有误治,如孙永昌等~([2])报道26例结节病在影像学检查诊断的第一印象中拟诊结核5例,其中就有2例完成规范的抗结核治疗,为此应引起临床对本病诊治的重视。
1,821 citations
TL;DR: A more positive fluid balance both early in resuscitation and cumulatively over 4 days is associated with an increased risk of mortality in septic shock.
Abstract: Objective:To determine whether central venous pressure and fluid balance after resuscitation for septic shock are associated with mortality.Design:We conducted a retrospective review of the use of intravenous fluids during the first 4 days of care.Setting:Multicenter randomized controlled trial.Pati
1,191 citations
TL;DR: Dynamic changes of arterial waveform-derived variables during mechanical ventilation are highly accurate in predicting volume responsiveness in critically ill patients with an accuracy greater than that of traditional static indices of volume responsiveness.
Abstract: Objectives:A systematic review of the literature to determine the ability of dynamic changes in arterial waveform-derived variables to predict fluid responsiveness and compare these with static indices of fluid responsiveness. The assessment of a patient's intravascular volume is one of the most dif
1,062 citations