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Bodil B. Carstens
Researcher at University of Queensland
Publications - 7
Citations - 148
Bodil B. Carstens is an academic researcher from University of Queensland. The author has contributed to research in topics: Conotoxin & Receptor. The author has an hindex of 5, co-authored 7 publications receiving 138 citations.
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Journal ArticleDOI
Structure-Activity Studies of Cysteine-Rich α-Conotoxins that Inhibit High-Voltage-Activated Calcium Channels via GABA(B) Receptor Activation Reveal a Minimal Functional Motif.
Bodil B. Carstens,Géza Berecki,James T. Daniel,Han Siean Lee,Kathryn A. V. Jackson,Han-Shen Tae,Han-Shen Tae,Mahsa Sadeghi,Mahsa Sadeghi,Joel Castro,Tracy O'Donnell,Annemie Deiteren,Stuart M. Brierley,David J. Craik,David J. Adams,David J. Adams,Richard J. Clark +16 more
TL;DR: Structural determination by NMR spectroscopy helped to identify a simplified biologically active eight residue peptide motif containing a single disulfide bond that is an excellent lead molecule for developing a new generation of analgesic peptide drugs.
Journal ArticleDOI
Engineering of Conotoxins for the Treatment of Pain
Bodil B. Carstens,Richard J. Clark,Norelle L. Daly,Peta J. Harvey,Quentin Kaas,David J. Craik +5 more
TL;DR: Structural and biological studies on several classes of conotoxins that have potential as drug leads for the treatment of pain are discussed, suggesting that cyclization is a generally applicable approach to conotoxin stabilization.
Journal ArticleDOI
Structure-Activity Studies Reveal the Molecular Basis for GABAB-Receptor Mediated Inhibition of High Voltage-Activated Calcium Channels by α-Conotoxin Vc1.1.
Mahsa Sadeghi,Bodil B. Carstens,Brid P Callaghan,James T. Daniel,Han-Shen Tae,Tracey A. O'Donnell,Joel Castro,Stuart M. Brierley,David J. Adams,David J. Craik,Richard J. Clark +10 more
TL;DR: Findings suggest that selectively targeting GABABR-mediated HVA calcium channel inhibition by α-conotoxins could be effective for the treatment of chronic visceral pain.
Journal ArticleDOI
Isolation, Characterization, and Synthesis of the Barrettides: Disulfide-Containing Peptides from the Marine Sponge Geodia barretti.
Bodil B. Carstens,K. Johan Rosengren,Sunithi Gunasekera,Stefanie Schempp,Lars Bohlin,Mia Dahlström,Richard J. Clark,Ulf Göransson +7 more
TL;DR: Two disulfide-containing peptides, barrettides A and B, from the cold-water marine sponge Geodia barretti, were found not to inhibit the growth of either Escherichia coli or Staphylococcus aureus but displayed antifouling activity against barnacle larvae without lethal effects in the concentrations tested.
Journal ArticleDOI
Effects of linker sequence modifications on the structure, stability, and biological activity of a cyclic α-conotoxin.
Bodil B. Carstens,Joakim E. Swedberg,Géza Berecki,David J. Adams,David J. Craik,Richard J. Clark +5 more
TL;DR: The results suggest the linker sequence might be a useful part of the molecule for optimization of bioactivity and not just the physiochemical properties of cVc1.1, a promising lead molecule for the development of new treatments for neuropathic and chronic pain.