Author
Boguslaw Habrat
Bio: Boguslaw Habrat is an academic researcher from Pomeranian Medical University. The author has contributed to research in topics: Taste & Methadone. The author has an hindex of 10, co-authored 23 publications receiving 386 citations.
Topics: Taste, Methadone, Abstinence, Delirium tremens, Alcohol dependence
Papers
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TL;DR: In humans ethanol tastes both bitter and sweet, suggesting that the relationship between sucrose and ethanol intakes previously found in animals and humans may result, at least partially, from similar taste responses elicited by suc rose and ethanol.
116 citations
TL;DR: It is suggested that increased aversive responses to salt taste may predict future development of alcohol dependence.
Abstract: The aim of the present study was to compare taste responses (intensity and pleasantness/unpleasantness) to sweet, bitter, sour, and salty solutions in sons of male alcoholics (SOMAs) and control subjects with no family history of alcoholism. In addition, responses to Coca-Cola flavour were evaluated in both groups. Unpleasantness of salty solutions was significantly enhanced and intensity of sour solutions tended to be higher in the SOMAs. There were no other differences between the groups. Thus, contrary to previous suggestions, genetically determined vulnerability to alcohol dependence may not be associated with altered responses to sweet substances. The present findings would rather suggest that increased aversive responses to salt taste may predict future development of alcohol dependence.
47 citations
TL;DR: The aim of the present study was to compare taste responses to sweet, bitter, sour and salty solutions in male alcoholics and control subjects and found that the groups did not differ in terms of rated intensity or pleasantness.
Abstract: The aim of the present study was to compare taste responses to sweet, bitter, sour and salty solutions in male alcoholics and control subjects. The groups did not differ in terms of rated intensity or pleasantness of sucrose (1-30%), quinine (0.001-0.005%), citric acid (0.02-0.1%) and sodium chloride (0.18-0.9%) solutions. The proportion of sweet-likers was also similar in both groups.
40 citations
TL;DR: In this article, the authors compared taste responses to sweet, bitter, sour, and salty solutions in methadone-maintained opioid-dependent men and healthy control subjects and found that participants reported adding more table sugar to caffeinated beverages.
34 citations
01 Jan 2002
TL;DR: The results of the present study suggest that changes in taste reactivity may not be responsible for altered dietary choices in opioid addicts.
Abstract: It has been shown repeatedly that opioid dependence is associated with increased consumption of refined sugars. It is possible that this association results from altered taste reactivity in opioid-dependent subjects. Thus, in the present study, we compared taste responses to sweet, bitter, sour and salty solutions in methadone-maintained opioid-dependent men and healthy control subjects. The two groups did not differ in terms of rated intensity or pleasantness of sucrose (1/30%), quinine (0.001/0.005%), citric acid (0.02/0.1%) and sodium chloride (0.18/0.9%) solutions. Proportions of ‘sweet-likers’, i.e. subjects rating a 30% sucrose (0.88 M) solution as the most pleasant, were also similar in both groups. In line with the previous findings, the methadone-maintained subjects reported adding more table sugar to caffeinated beverages. The results of the present study suggest that changes in taste reactivity may not be responsible for altered dietary choices in opioid addicts. # 2002 Elsevier Science Ireland Ltd. All rights reserved.
30 citations
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Journal Article•
TL;DR: Double-blind studies of the efficacy of pharmacological agents that potently inhibit 5-HT uptake in the treatment of mental retardation coexisting with Axis I psychiatric disorders (especially obsessive-compulsive disorder) and autistic disorder are warranted.
Abstract: An open trial of pharmacological treatment with fluoxetine, ranging from 20 mg every other day to 80 mg per day, led to a significant improvement in Clinical Global Impressions ratings of Clinical Severity in 15 of 23 subjects with autistic disorder and 10 of 16 subjects with mental retardation Six of 23 patients with autistic disorder and 3 of 16 patients with mental retardation had side effects which significantly interfered with function, consisting predominantly of restlessness, hyperactivity, agitation, decreased appetite, or insomnia Double-blind studies of the efficacy of pharmacological agents that potently inhibit 5-IIT uptake in the treatment of mental retardation coexisting with Axis I psychiatric disorders (especially obsessive-compulsive disorder) and autistic disorder are warranted
238 citations
TL;DR: In this article, the effects of pH, ethanol level and tartaric acid concentration in modifying astringency and bitterness of oligomeric tannins in model wine solutions were explored.
235 citations
TL;DR: It is suggested that it might be more useful to focus on overeating that results in frank obesity, and multiple health, interpersonal, and occupational negative consequences as a form of food "abuse".
230 citations
TL;DR: Future research starting from a subjective, multidimensional approach of the concept of QoL is required, as the chronic nature of drug use problems creates the necessity to look at outcomes beyond the direct consequences of drug dependence and based on clients' needs.
185 citations
TL;DR: New biomarkers, not yet used in routine clinical work, include phosphatidylethanol, fatty acid ethyl esters, ethyl glucuronide, sialic acid, and acetaldehyde adducts.
Abstract: Alcohol and alcohol-related diseases have become a major cause of death in Western countries. The most sensitive and specific of the commonly used biomarkers of alcohol intake are carbohydrate-deficient transferrin (CDT), and the combination of gamma-glutamyltransferase (GGT) and CDT. Other widely used laboratory markers are GGT, mean corpuscular volume of erythrocytes and the ratio of aspartate aminotransferase to alanine aminotransferase. Blood ethanol levels reveal recent alcohol use. However, more specific and sensitive biomarkers to improve the detection of excessive alcohol use at an early stage are needed. New biomarkers, not yet used in routine clinical work, include phosphatidylethanol, fatty acid ethyl esters, ethyl glucuronide, sialic acid, and acetaldehyde adducts.
176 citations