Boontida Morakul

Bio: Boontida Morakul is an academic researcher from Mahidol University. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 4, co-authored 6 publications receiving 326 citations.

Niosomal delivery of pumpkin seed oil: development, characterisation, and physical stability.

Abstract: Pumpkin seed oil (PSO) provides many health benefits including antioxidant, cardiovascular health boost, treatment of benign prostatic hyperplasia (BPH), and reduction of hair loss. The main objective of this study was to design a suitable formulation of niosomes encapsulated PSO for topical delivery. Formulation of PSO-loaded niosomes was optimised by altering the types of surfactant and the amount of PSO:surfactant:cholesterol. The developed PSO-loaded niosomes were spherical shape with the size range of 138-366 nm. The niosomes formulated with Tween 20 provided the smallest particle size. An increase in the ratio of PSO:surfactant:cholesterol from 2:2:1 to 2:4:1 led to reduction of the particle size of the niosomes. The PSO-loaded niosomes formulation F1 (PSO:Tween 20:cholesterol = 2:2:1) provided the highest percent entrapment efficacy at 75.99 ± 14.65%. The in vitro release study suggested that the release mechanism was followed Korsmeyer-Peppas. The physical stability study indicated good stability over 3 months of storage at 30 °C.

Self-nanoemulsifying drug delivery systems (SNEDDS): an advancement technology for oral drug delivery

Abstract: Nanotechnology is strongly accepted as the crucial approach in drug delivery that can influence the therapeutic performance of hydrophobic drugs. Self-nanoemulsifying drug delivery systems (SNEDDS) are one of the proven methods that can increase solubility and bioavailability of poorly water soluble drugs. SNEDDS are anhydrous homogenous liquid mixtures consisting of oil, surfactant, co-surfactant, and drugs, which spontaneously form o/w nanoemulsions when diluted with water under gentle agitation. SNEDDS provide several potential effects on oral drug delivery. This article presents an overview of SNEDDS along with their basics; such as, composition, preparation, characterization, potential effects associated with oral delivery, applications, commercially available products, advanced technology associated with SNEDDS, and trending.

Nano based drug delivery systems: recent developments and future prospects

Abstract: Nanomedicine and nano delivery systems are a relatively new but rapidly developing science where materials in the nanoscale range are employed to serve as means of diagnostic tools or to deliver therapeutic agents to specific targeted sites in a controlled manner Nanotechnology offers multiple benefits in treating chronic human diseases by site-specific, and target-oriented delivery of precise medicines Recently, there are a number of outstanding applications of the nanomedicine (chemotherapeutic agents, biological agents, immunotherapeutic agents etc) in the treatment of various diseases The current review, presents an updated summary of recent advances in the field of nanomedicines and nano based drug delivery systems through comprehensive scrutiny of the discovery and application of nanomaterials in improving both the efficacy of novel and old drugs (eg, natural products) and selective diagnosis through disease marker molecules The opportunities and challenges of nanomedicines in drug delivery from synthetic/natural sources to their clinical applications are also discussed In addition, we have included information regarding the trends and perspectives in nanomedicine area

Therapeutic Nanoparticles and Their Targeted Delivery Applications.

Abstract: Nanotechnology offers many advantages in various fields of science. In this regard, nanoparticles are the essential building blocks of nanotechnology. Recent advances in nanotechnology have proven that nanoparticles acquire a great potential in medical applications. Formation of stable interactions with ligands, variability in size and shape, high carrier capacity, and convenience of binding of both hydrophilic and hydrophobic substances make nanoparticles favorable platforms for the target-specific and controlled delivery of micro- and macromolecules in disease therapy. Nanoparticles combined with the therapeutic agents overcome problems associated with conventional therapy; however, some issues like side effects and toxicity are still debated and should be well concerned before their utilization in biological systems. It is therefore important to understand the specific properties of therapeutic nanoparticles and their delivery strategies. Here, we provide an overview on the unique features of nanoparticles in the biological systems. We emphasize on the type of clinically used nanoparticles and their specificity for therapeutic applications, as well as on their current delivery strategies for specific diseases such as cancer, infectious, autoimmune, cardiovascular, neurodegenerative, ocular, and pulmonary diseases. Understanding of the characteristics of nanoparticles and their interactions with the biological environment will enable us to establish novel strategies for the treatment, prevention, and diagnosis in many diseases, particularly untreatable ones.

Multifunctional nanocrystals for cancer therapy: a potential nanocarrier

Abstract: Nanotechnology-based drug delivery systems offer an unprecedented opportunity for tumor targeting. Nanocrystals are carrier-free crystalline nanosized solid drug particles. Due to high drug loading (as high as 100%), and being free of organic solvents or surfactants or polymers or solubilizing chemicals, nanocrystals have attracted great attention in the field of drug delivery for treatment of various cancers. Additionally, the hybrid or multifunctional nanocrystal has been extensively investigated for applications in experimental as well as clinical settings to improve delivery efficiency of therapeutic and diagnostic agents. This review gives an overview of recent advances and current status of nanocrystals, especially with respect to the method of preparations, physicochemical characterizations, in vitro/in vivo performance, scale-up techniques and applications in the field of drug delivery for different tumor targeting. Recently much attention has been given to multifunctional nanocrystals showing the capability to codeliver multiple components that target the drug delivery by surface functionalization, performing therapy as well as diagnosis. Preparative techniques like high-pressure homogenization, precipitation, and media milling have been known to show large-scale production of nanocrystals. High therapeutic applications of nanoparticles enable its administration through various routes like oral, parenteral, pulmonary, dermal, and ocular. Along with preparation and characterization, this review will dwell on the progress involved with multifunctional nanocrystals for cancer therapy and theranostics. Most available results in multifunctional nanocrystal targeting rely upon in vitro and animal models, which do not match the actual environment of the tumor in the body, which is one of the major obstacles. Other challenges faced when it comes to nanocrystals are scale-up and reproducibility. In addition, potential problems and possible future research directions for the advancement of newer techniques of multifunctional nanocrystals that make them highly suitable for tumor targeted are highlighted in this review.