B
Brad Efron
Researcher at Stanford University
Publications - 5
Citations - 2082
Brad Efron is an academic researcher from Stanford University. The author has contributed to research in topics: Transcriptome & Resistance mutation. The author has an hindex of 5, co-authored 5 publications receiving 1996 citations.
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Journal ArticleDOI
Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages Insights into the Phagosomal Environment
Dirk Schnappinger,Sabine Ehrt,Martin I. Voskuil,Yang Liu,Joseph A. Mangan,Irene M. Monahan,Gregory Dolganov,Brad Efron,Philip D. Butcher,Carl Nathan,Gary K. Schoolnik +10 more
TL;DR: The microbial transcriptome served as a bioprobe of the MTB phagosomal environment, showing it to be nitrosative, oxidative, functionally hypoxic, carbohydrate poor, and capable of perturbing the pathogen's cell envelope.
Journal ArticleDOI
Impact of HIV-1 subtype and antiretroviral therapy on protease and reverse transcriptase genotype: Results of a global collaboration
Rami Kantor,David Katzenstein,Brad Efron,Ana Patricia Carvalho,Brian Wynhoven,Patricia A. Cane,John R. Clarke,Sunee Sirivichayakul,Marcelo A. Soares,Joke Snoeck,Candice Pillay,H Rudich,Rosangela Rodrigues,África Holguín,Koya Ariyoshi,María Belén Bouzas,Pedro Cahn,Wataru Sugiura,Vincent Soriano,Luís Fernando de Macedo Brígido,Z Grossman,Lynn Morris,Anne-Mieke Vandamme,Amilcar Tanuri,Praphan Phanuphak,Jonathan Weber,Deenan Pillay,P. Richard Harrigan,Ricardo Jorge Camacho,Jonathan M. Schapiro,Robert W. Shafer +30 more
TL;DR: Global surveillance and genotypic assessment of drug resistance should focus primarily on the known subtype B drug-resistance mutations.
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HIV-1 genotypic resistance patterns predict response to saquinavir-ritonavir therapy in patients in whom previous protease inhibitor therapy had failed.
Andrew R. Zolopa,Robert W. Shafer,Ann Warford,Jose G. Montoya,Phillip Hsu,David Katzenstein,Thomas C. Merigan,Brad Efron +7 more
TL;DR: Whether HIV-1 reverse transcriptase and protease genotype predicts virologic response to saquinavirritonavir combination therapy in patients in whom therapy with at least one protease inhibitor-containing antiretroviral regimen had failed is investigated.
Journal ArticleDOI
A meta-analysis of peritoneal drainage versus laparotomy for perforated necrotizing enterocolitis.
TL;DR: It is not possible to determine whether PPD or LAP is superior for treatment of perforated necrotizing enterocolitis, and only a randomized trial will determine which operation is best for the treatment ofperforated NEC.
Journal ArticleDOI
Didanosine Resistance in HIV-infected Patients Switched from Zidovudine to Didanosine Monotherapy
Michael J. Kozal,Kenda L. Kroodsma,Mark A. Winters,Robert W. Shafer,Brad Efron,David Katzenstein,Thomas C. Merigan +6 more
TL;DR: Serum HIV RNA was obtained from patients who were switched from zidovudine to didanosine therapy and the relation of the codon 74 mutation in patient serum HIV RNA to changes in CD4+ T-cell levels and HIV virus burden was examined.