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Bradford B. Lowell
Researcher at Beth Israel Deaconess Medical Center
Publications - 220
Citations - 59002
Bradford B. Lowell is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Adipose tissue & Hypothalamus. The author has an hindex of 101, co-authored 213 publications receiving 53866 citations. Previous affiliations of Bradford B. Lowell include Harvard University & University of Pennsylvania.
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Journal ArticleDOI
Mechanisms Controlling Mitochondrial Biogenesis and Respiration through the Thermogenic Coactivator PGC-1
Zhidan Wu,Pere Puigserver,Ulf Andersson,Chen-Yu Zhang,Guillaume Adelmant,Vamsi K. Mootha,Amy E Troy,Saverio Cinti,Bradford B. Lowell,Richard C. Scarpulla,Bruce M. Spiegelman +10 more
TL;DR: PGC-1, a cold-inducible coactivator of nuclear receptors, stimulates mitochondrial biogenesis and respiration in muscle cells through an induction of uncoupling protein 2 (UCP-2) and through regulation of the nuclear respiratory factors (NRFs).
Journal ArticleDOI
Role of leptin in the neuroendocrine response to fasting
Rexford S. Ahima,Daniel Prabakaran,Christos S. Mantzoros,Daqing Qu,Bradford B. Lowell,Eleftheria Maratos-Flier,Jeffrey S. Flier +6 more
TL;DR: It is proposed that regulation of the neuroendocrine system during starvation could be the main physiological role of leptin, and preventing the starvation-induced fall in leptin with exogenous leptin substantially blunts the changes in gonadal, adrenal and thyroid axes in male mice, and prevents the starve-induced delay in ovulation in female mice.
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Transcriptional co-activator PGC-1α drives the formation of slow-twitch muscle fibres
Jiandie D. Lin,Hai Wu,Paul T. Tarr,Chen-Yu Zhang,Zhidan Wu,Olivier Boss,Laura F. Michael,Pere Puigserver,Elji Isotani,Eric N. Olson,Bradford B. Lowell,Rhonda S Bassel-Duby,Bruce M. Spiegelman +12 more
TL;DR: Using fibre-type-specific promoters, it is shown in cultured muscle cells that PGC-1α activates transcription in cooperation with Mef2 proteins and serves as a target for calcineurin signalling, which has been implicated in slow fibre gene expression.
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Mitochondrial dysfunction and type 2 diabetes.
TL;DR: Emerging evidence supports the potentially unifying hypothesis that both of these prominent features of type 2 diabetes are caused by mitochondrial dysfunction.
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Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
Robert Frederich,Andreas Hamann,Stephen Anderson,Bettina Lollmann,Bradford B. Lowell,Jeffrey S. Flier +5 more
TL;DR: It is found that high-fat diet evokes a sustained increase in circulating leptin in both normal and transgenic mice, with leptin levels accurately reflecting the amount of body lipid across a broad range of body fat.