B
Braedon McDonald
Researcher at University of Calgary
Publications - 52
Citations - 7191
Braedon McDonald is an academic researcher from University of Calgary. The author has contributed to research in topics: Medicine & Neutrophil extracellular traps. The author has an hindex of 21, co-authored 39 publications receiving 5756 citations. Previous affiliations of Braedon McDonald include McGill University.
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Journal ArticleDOI
Platelet TLR4 activates neutrophil extracellular traps to ensnare bacteria in septic blood
Stephen Clark,Adrienne C. Ma,Samantha A. Tavener,Braedon McDonald,Zahra Goodarzi,Margaret M. Kelly,Kamala D. Patel,Subhadeep Chakrabarti,Erin F. McAvoy,Gary D. Sinclair,Elizabeth Keys,Emma Allen-Vercoe,Rebekah DeVinney,Christopher J. Doig,Francis H. Y. Green,Paul Kubes +15 more
TL;DR: It is proposed that platelet TLR4 is a threshold switch for this new bacterial trapping mechanism in severe sepsis, where NETs have the greatest capacity for bacterial trapping.
Journal ArticleDOI
Intravascular danger signals guide neutrophils to sites of sterile inflammation.
Braedon McDonald,Keir Pittman,Gustavo B. Menezes,Simon A. Hirota,Ingrid Slaba,Christopher C. M. Waterhouse,Paul L. Beck,Daniel A. Muruve,Paul Kubes +8 more
TL;DR: Dynamic in vivo imaging revealed a multistep hierarchy of directional cues that guide neutrophil localization to sites of sterile inflammation, and the underlying mechanisms of recruitment of neutrophils into injured tissue.
Journal ArticleDOI
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Jonathan Cools-Lartigue,Jonathan Spicer,Braedon McDonald,Stephen Gowing,Simon C. Chow,Betty Giannias,Paul Kubes,Lorenzo E. Ferri +7 more
TL;DR: It is reported that circulating tumor cells become trapped within NETs in vitro under static and dynamic conditions and NETs are identified as potential therapeutic targets in the context of systemic infection.
Journal ArticleDOI
Intravascular Neutrophil Extracellular Traps Capture Bacteria from the Bloodstream during Sepsis
TL;DR: It is shown that neutrophils migrate to liver sinusoids during endotoxemia and sepsis where they exert protective effects by releasing neutrophil extracellular traps, which are DNA-based structures that capture and eliminate microbes.
Journal ArticleDOI
Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice.
Braedon McDonald,Rachelle P. Davis,Seok-Joo Kim,Mandy Tse,Charles T. Esmon,Elzbieta Kolaczkowska,Craig N. Jenne +6 more
TL;DR: Together, these data demonstrate, for the first time in an in vivo model of infection, a dynamic NET-platelet-thrombin axis that promotes intravascular coagulation and microvascular dysfunction in sepsis.