B
Brandon DuGar
Researcher at Cleveland Clinic
Publications - 2
Citations - 4153
Brandon DuGar is an academic researcher from Cleveland Clinic. The author has contributed to research in topics: Proinflammatory cytokine & Inflammation. The author has an hindex of 2, co-authored 2 publications receiving 3344 citations.
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Journal ArticleDOI
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Zeneng Wang,Elizabeth Klipfell,Brian J. Bennett,Robert A. Koeth,Bruce S. Levison,Brandon DuGar,Ariel E. Feldstein,Earl B. Britt,Xiaoming Fu,Yoon-Mi Chung,Yuping Wu,Phil Schauer,Jonathan D. Smith,Hooman Allayee,W.H. Wilson Tang,Joseph A. DiDonato,Aldons J. Lusis,Stanley L. Hazen +17 more
TL;DR: Discovery of a relationship between gut-flora-dependent metabolism of dietary phosphatidylcholine and CVD pathogenesis provides opportunities for the development of new diagnostic tests and therapeutic approaches for atherosclerotic heart disease.
Journal ArticleDOI
The Critical Role of IL-1 Receptor-Associated Kinase 4-Mediated NF-κB Activation in Modified Low-Density Lipoprotein-Induced Inflammatory Gene Expression and Atherosclerosis
Tae Whan Kim,Maria Febbraio,Peggy Robinet,Brandon DuGar,Diane J. Greene,Anna M. Cerny,Eicke Latz,Raymond Gilmour,Kirk A. Staschke,Guy M. Chisolm,Paul L. Fox,Paul E. DiCorleto,Jonathan D. Smith,Xiaoxia Li +13 more
TL;DR: Examination of the role of IL-1R–associated kinase 4 (IRAK4) kinase activity in modified low-density lipoprotein (LDL)-mediated signaling using bone marrow-derived macrophage as well as an in vivo model of atherosclerosis indicates that the IRAK4 kinase plays an important role in modified LDL-mediated signaling and the development of Atherosclerosis.