B
Brant M. Weinstein
Researcher at National Institutes of Health
Publications - 146
Citations - 18463
Brant M. Weinstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Zebrafish & Angiogenesis. The author has an hindex of 58, co-authored 142 publications receiving 16708 citations. Previous affiliations of Brant M. Weinstein include Howard Hughes Medical Institute & Harvard University.
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In vivo imaging of embryonic vascular development using transgenic zebrafish.
TL;DR: It is found that the zebrafish fli1 promoter is able to drive expression of enhanced green fluorescent protein (EGFP) in all blood vessels throughout embryogenesis, and these transgenic lines allow detailed analysis of both wild type and mutant embryonic vasculature.
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Notch signaling is required for arterial-venous differentiation during embryonic vascular development.
Nathan D. Lawson,Nico Scheer,Van N. Pham,Cheol-Hee Kim,Ajay B. Chitnis,José A. Campos-Ortega,Brant M. Weinstein +6 more
TL;DR: The results suggest that notch signaling is required for the proper development of arterial and venous blood vessels, and that a major role of Notch signaling in blood vessels is to repress venous differentiation within developing arteries.
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The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development.
TL;DR: A highly dynamic but also highly stereotypic pattern of vascular connections is found, with different sets of primitive embryonic vessels severing connections and rewiring in new configurations according to a reproducible plan.
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sonic hedgehog and vascular endothelial growth factor Act Upstream of the Notch Pathway during Arterial Endothelial Differentiation
TL;DR: It is found that vascular endothelial growth factor acts downstream of sonic hedgehog and upstream of the Notch pathway to determine arterial cell fate, and differential effects of Vegf on developing endothelial cells are suggested.
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The Control of Vascular Integrity by Endothelial Cell Junctions: Molecular Basis and Pathological Implications
Elisabetta Dejana,Elisabeth Tournier-Lasserve,Elisabeth Tournier-Lasserve,Brant M. Weinstein +3 more
TL;DR: This review discusses recent findings derived from basic cell biology, clinical studies, and studies in animal models such as mice and zebrafish and their possible integration in a common picture of human pathologies.