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Brenda I. Gerwin
Researcher at National Institutes of Health
Publications - 75
Citations - 4200
Brenda I. Gerwin is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Cell culture & Murine leukemia virus. The author has an hindex of 31, co-authored 75 publications receiving 4127 citations. Previous affiliations of Brenda I. Gerwin include Wayne State University & United States Atomic Energy Commission.
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Journal Article
Transformation of Human Bronchial Epithelial Cells by Infection with SV40 or Adenovirus-12 SV40 Hybrid Virus, or Transfection via Strontium Phosphate Coprecipitation with a Plasmid Containing SV40 Early Region Genes
Roger R. Reddel,Yang Ke,Brenda I. Gerwin,Mary G. McMenamin,John F. Lechner,Robert T. Su,Douglas E. Brash,Joo-Bae Park,Johng S. Rhim,Curtis C. Harris +9 more
TL;DR: Normal human bronchial epithelial cells were infected with SV40 virus or an adenovirus 12-SV40 hybrid virus, or transfected via strontium phosphate coprecipitation with plasmids containing the SV40 early region genes, and Colonies of morphologically altered cells were isolated and cultured.
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Mutations and altered expression of p16INK4 in human cancer
A. Okamoto,Douglas J. Demetrick,Elisa A. Spillare,Koichi Hagiwara,S.P. Hussain,William P. Bennett,Kathleen Forrester,Brenda I. Gerwin,Manuel Serrano,David Beach +9 more
TL;DR: Results are consistent with the hypothesis that p16INK4 is a tumor-suppressor protein and that genetic and epigenetic abnormalities in genes controlling the G1 checkpoint can lead to both escape from senescence and cancer formation.
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Oncogenes and tumor-suppressor genes.
Teresa A. Lehman,Roger R. Reddel,A M Peiifer,E Spillare,M E Kaighn,Ainsley Weston,Brenda I. Gerwin,Curtis C. Harris +7 more
TL;DR: In addition to studying the pathogenic role of oncogenes, this work is attempting to define negative growth-regulating genes that have tumor-suppressive effects for human lung carcinomas, and involves loss of heterozygosity studies, monochromosome- cell fusion, and cell-cell fusion studies.
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Human bronchial epithelial cells with integrated SV40 virus T antigen genes retain the ability to undergo squamous differentiation
Yang Ke,Roger R. Reddel,Brenda I. Gerwin,Masao Miyashita,Mary G. McMenamin,John F. Lechner,Curtis C. Harris +6 more
TL;DR: Two phenotypically different subclones provide a new in vitro cellular system for delineating the mechanism(s) of human bronchial epithelial cell squamous differentiation in response to FBS or TGF-beta 1.
Journal Article
Comparison of Production of Transforming Growth Factor-β and Platelet-derived Growth Factor by Normal Human Mesothelial Cells and Mesothelioma Cell Lines
Brenda I. Gerwin,John F. Lechner,Roger R. Reddel,Anita B. Roberts,Keith C. Robbins,Edward W. Gabrielson,Curtis C. Harris +6 more
TL;DR: PDGF-like mitogenic activity was readily detectable in medium conditioned by a mesothelioma cell line and was undetectable in conditioned medium from normal cells, suggesting the hypothesis that PDGF may be an autocrine growth factor in mesothelialioma.